Sistema de Salut de Catalunya
Institut Català de la Salut
[Doulaptsi M] Department of Otorhinolaryngology, Head and Neck Surgery, University of Crete School of Medicine, Heraklion, Crete, Greece. KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research group, Leuven, Belgium. [Wils T, Martens K] KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research group, Leuven, Belgium. [Hellings PW] KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research group, Leuven, Belgium. University Hospitals Leuven, Clinical Department of Otorhinolaryngology, Head and Neck Surgery, Leuven, Belgium. Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands. University of Ghent, Department of Otorhinolaryngology, Laboratory of Upper Airways Research, Ghent, Belgium. [Farré R] KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Leuven, Belgium. [Vicario M] Unitat de Recerca en Malalties Digestives, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Gastroenterologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
2022-04-25T10:04:38Z
2022-04-25T10:04:38Z
2021-09-11
Rinitis alérgica; Integridad epitelial; Furoato de mometasona
Rinitis al·lèrgica; Integritat epitelial; Furoat de mometasona
Allergic rhinitis; Epithelial integrity; Mometasone furoate
Tight junction defects (TJ) have been associated with a defective epithelial barrier function in allergic rhinitis (AR). Intranasal corticosteroids are potent drugs frequently used to treat AR and are shown to restore epithelial integrity by acting on TJs and by reducing type 2 cytokine production. However, the effect of different classes of intranasal corticosteroids on the epithelial barrier has not been studied. Therefore, we compared the effect of 2 intranasal corticosteroids, ie, fluticasone furoate (FF) and mometasone furoate (MF) on epithelial barrier function. Both FF and MF similarly increased trans-epithelial electrical resistance of primary nasal epithelial cell cultures from AR patients. In a house dust mite-induced allergic asthma mouse model, FF and MF had similar beneficial effects on fluorescein isothiocyanate–dextran 4 kDa mucosal permeability, eosinophilic infiltration and IL-13 levels. Both molecules increased mRNA expression of the TJ proteins occludin and zonula occludens-1, thereby restoring epithelial barrier function. Lastly, we showed that long-term FF treatment also increased expression of occludin in AR patients compared to controls. In conclusion, both FF and MF effectively restore epithelial barrier function by increasing expression of TJ proteins in AR patients.
This work was supported by an unrestricted grant from GSK. BS is supported by the Fund for Scientific Research Flanders (FWO), Belgium.
Article
Published version
English
Rinitis - Tractament; Cèl·lules epitelials; Medicaments - Efectes fisiològics; DISEASES::Respiratory Tract Diseases::Nose Diseases::Rhinitis::Rhinitis, Allergic; Other subheadings::Other subheadings::Other subheadings::/drug therapy; ANATOMY::Cells::Epithelial Cells; Other subheadings::Other subheadings::/drug effects; ENFERMEDADES::enfermedades respiratorias::enfermedades nasales::rinitis::rinitis alérgica; Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia; ANATOMÍA::células::células epiteliales; Otros calificadores::Otros calificadores::/efectos de los fármacos
Elsevier
World Allergy Organization Journal;14(9)
https://doi.org/10.1016/j.waojou.2021.100585
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Articles científics - HVH [3440]
