dc.contributor
Institut Català de la Salut
dc.contributor
[Zapatero A] Department of Radiation Oncology, Hospital Universitario de La Princesa, Madrid, Spain. [Maldonado Pijoan X] Servei d’Oncologia Radioteràpica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Gómez-Caamaño A] Department of Radiation Oncology, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain. [Pardo Masferrer J] Department of Radiation Oncology, Hospital Universitari Son Espases, Palma de Mallorca, Spain. [Macías Hernández V] Hospital Universitario Y Politecnico La Fe, Valencia, Spain. [Hervás Morón A] Department of Radiation Oncology, Hospital Ramon Y Cajal, Madrid, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Zapatero, Almudena
dc.contributor.author
Maldonado Pijoan, Javier
dc.contributor.author
Gómez‑Caamaño, Antonio
dc.contributor.author
Pardo Masferrer, José
dc.contributor.author
Macías Hernández, Víctor
dc.contributor.author
Hervás Morón, Asunción
dc.date.accessioned
2025-10-24T10:39:55Z
dc.date.available
2025-10-24T10:39:55Z
dc.date.issued
2022-04-25T12:56:33Z
dc.date.issued
2022-04-25T12:56:33Z
dc.date.issued
2021-09-25
dc.identifier
Zapatero A, Maldonado Pijoan X, Gómez-Caamaño A, Pardo Masferrer J, Macías Hernández V, Hervás Morón A, et al. Health-related quality of life in men with localized prostate cancer treated with radiotherapy: validation of an abbreviated version of the Expanded Prostate Cancer Index Composite for Clinical Practice in Spain. Health Qual Life Outcomes. 2021 Sep 25;19:223.
dc.identifier
https://hdl.handle.net/11351/7394
dc.identifier
10.1186/s12955-021-01856-z
dc.identifier
000699023500002
dc.identifier.uri
https://hdl.handle.net/11351/7394
dc.description.abstract
Cáncer de próstata; Evaluación de la calidad de vida; Radioterapia
dc.description.abstract
Càncer de pròstata; Avaluació de la qualitat de vida; Radioteràpia
dc.description.abstract
Prostate cancer; Quality-of-life assessment; Radiotherapy
dc.description.abstract
Background
Health-related quality of life (HRQoL) is greatly affected by prostate cancer (PCa) and associated treatments. This study aimed to measure the impact of radiotherapy on HRQoL and to further validate the Spanish version of the 16-item Expanded Prostate Cancer Index Composite (EPIC-16) in routine clinical practice.
Methods
An observational, non-interventional, multicenter study was conducted in Spain with localized PCa patients initiating treatment with external beam radiotherapy (EBRT) or brachytherapy (BQT). Changes from baseline in EPIC-16, University of California-Los Angeles Prostate Cancer Index (UCLA-PCI), and patient-perceived health status were longitudinally assessed at end of radiotherapy (V2) and 90 days thereafter (V3). Psychometric evaluations of the Spanish EPIC-16 were conducted.
Results
Of 516 patients enrolled, 495 were included in the analysis (EBRT, n = 361; BQT, n = 134). At baseline, mean (standard deviation [SD]) EPIC-16 global scores were 11.9 (7.5) and 10.3 (7.7) for EBRT and BQT patients, respectively; scores increased, i.e., HRQoL worsened, from baseline, by mean (SD) of 6.8 (7.6) at V2 and 2.4 (7.4) at V3 for EBRT and 4.2 (7.6) and 3.9 (8.2) for BQT patients. Changes in Spanish EPIC-16 domains correlated well with urinary, bowel, and sexual UCLA-PCI domains. EPIC-16 showed good internal consistency (Cronbach’s alpha = .84), reliability, and construct validity.
Conclusion
The Spanish EPIC-16 questionnaire demonstrated sensitivity, strong discriminative properties and reliability, and validity for use in clinical practice. EPIC-16 scores worsened after radiotherapy in different HRQoL domains; however, a strong tendency towards recovery was seen at the 3-month follow-up visit.
dc.description.abstract
This study was funded by Astellas Pharma Inc.
dc.format
application/pdf
dc.format
application/pdf
dc.relation
Health and Quality of Life Outcomes;19
dc.relation
https://doi.org/10.1186/s12955-021-01856-z
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Pròstata - Càncer - Radioteràpia
dc.subject
Avaluació de resultats (Assistència sanitària)
dc.subject
DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms
dc.subject
Other subheadings::Other subheadings::Other subheadings::/radiotherapy
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of Results
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires
dc.subject
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::diseño de la investigación epidemiológica::reproducibilidad de los resultados
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios
dc.title
Health-related quality of life in men with localized prostate cancer treated with radiotherapy: validation of an abbreviated version of the Expanded Prostate Cancer Index Composite for Clinical Practice in Spain
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
