Sistema de Salut de Catalunya
Institut Català de la Salut
[Santos García D, Cores Bartolomé C, Naya Ríos L, García Roca L, Martínez Miró C] CHUAC, Complejo Hospitalario Universitario de A Coruña, 15006 A Coruña, Spain. [de Deus Fonticoba T] 2 CHUF, Complejo Hospitalario Universitario de Ferrol, 15405 A Coruña, Spain. [Hernández Vara J, de Fábregues O] Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2022-05-02T13:07:11Z
2022-05-02T13:07:11Z
2021-10
Enfermedad de Parkinson; Dependencia; Discapacidad
Malaltia de Parkinson; Dependència; Discapacitat
Parkinson’s disease; Dependency; Disability
Background and objective: The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson’s disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD). Patients and Methods: PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S&E-ADLS) at V0 and V2. FD was defined as an S&E-ADLS score less than 80%. Results: In the PD group, a significant decrease in the S&E-ADLS score from V0 to V2 (N = 507; from 88.58 ± 10.19 to 84.26 ± 13.38; p < 0.0001; Cohen’s effect size = −0.519) was observed but not in controls (N = 124; from 98.87 ± 6.52 to 99.52 ± 2.15; p = 0.238). When only patients considered functional independent at baseline were included, 55 out of 463 (11.9%) converted to functional dependent at V2. To be a female (OR = 2.908; p = 0.009), have longer disease duration (OR = 1.152; p = 0.002), have a non-tremoric motor phenotype at baseline (OR = 3.574; p = 0.004), have a higher score at baseline in FOGQ (OR = 1.244; p < 0.0001) and BDI-II (OR = 1.080; p = 0.008), have a lower score at baseline in PD-CRS (OR = 0.963; p = 0.008), and have a greater increase in the score from V0 to V2 in UPDRS-IV (OR = 1.168; p = 0.0.29), FOGQ (OR = 1.348; p < 0.0001) and VAFS-Mental (OR = 1.177; p = 0.013) (adjusted R-squared 0.52; Hosmer and Lemeshow test = 0.94) were all found to be independent predictors of FD at V2. Conclusions: In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term.
Fundación Curemos el Parkinson
Article
Published version
English
Parkinson, Malaltia de - Complicacions; Parkinson, Malaltia de - Prognosi; Discapacitats; DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson Disease; Other subheadings::Other subheadings::Other subheadings::/complications; DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression; DISEASES::Nervous System Diseases::Neurologic Manifestations::Gait Disorders, Neurologic; ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson; Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones; ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::progresión de la enfermedad; ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::trastornos neurológicos de la marcha
MDPI
Diagnostics;11(10)
https://doi.org/10.3390/diagnostics11101801
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
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