dc.contributor
Institut Català de la Salut
dc.contributor
[Granziera C] Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland. Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland. [Wuerfel J] Medical Image Analysis Center, Basel, Switzerland. Quantitative Biomedical Imaging Group (qbig), Department of Biomedical Engineering, University of Basel, Basel, Switzerland. [Barkhof F] Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, multiple sclerosis Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands. UCL Institutes of Healthcare Engineering and Neurology, London, UK. [Calabrese M] Neurology B, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. [De Stefano N] Neurology, Department of Medicine, Surgery and Neuroscience, University of Siena, Italy. [Enzinger C] Department of Neurology and Division of Neuroradiology, Medical University of Graz, Graz, Austria. [Rovira À] Grup de Recerca en Neuroradiologia, Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Granziera, Cristina
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Wuerfel, Jens
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Enzinger, Christian
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Rovira Cañellas, Alex
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Barkhof, Frederik
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Calabrese, Massimiliano
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De Stefano, Nicola
dc.date.issued
2022-06-15T10:44:10Z
dc.date.issued
2022-06-15T10:44:10Z
dc.identifier
Granziera C, Wuerfel J, Barkhof F, Calabrese M, De Stefano N, Enzinger C, et al. Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis. Brain. 2021 May;144(5):1296–1311.
dc.identifier
https://hdl.handle.net/11351/7680
dc.identifier
10.1093/brain/awab029
dc.identifier
000710927500019
dc.description.abstract
Imaging; Multiple sclerosis; Quantitative MRI
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Imatges; Esclerosi múltiple; Ressonància magnètica quantitativa
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Imágenes; Esclerosis múltiple; Resonancia magnética cuantitativa
dc.description.abstract
Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS, which can be compared across CNS regions, patients, and centres. In patients with multiple sclerosis, quantitative MRI techniques such as relaxometry, myelin imaging, magnetization transfer, diffusion MRI, quantitative susceptibility mapping, and perfusion MRI, complement conventional MRI techniques by providing insight into disease mechanisms. These include: (i) presence and extent of diffuse damage in CNS tissue outside lesions (normal-appearing tissue); (ii) heterogeneity of damage and repair in focal lesions; and (iii) specific damage to CNS tissue components. This review summarizes recent technical advances in quantitative MRI, existing pathological validation of quantitative MRI techniques, and emerging applications of quantitative MRI to patients with multiple sclerosis in both research and clinical settings. The current level of clinical maturity of each quantitative MRI technique, especially regarding its integration into clinical routine, is discussed. We aim to provide a better understanding of how quantitative MRI may help clinical practice by improving stratification of patients with multiple sclerosis, and assessment of disease progression, and evaluation of treatment response.
dc.description.abstract
C.G. is supported by the Swiss National Science Foundation (SNSF) grant PP00P3_176984, the Stiftung zur Förderung der gastroenterologischen und allgemeinen klinischen Forschung and the EUROSTAR E! 113682 HORIZON2020. F.B. is supported by the National Institute for Health Research biomedical research center at University College London Hospitals. J.W. is supported by the EU Horizon2020 research and innovation grant (FORCE, 668039). D.S.R. is supported by the Intramural Research Program of National Institute of Neurological Disorders and Stroke, National Institutes of Health. A.T.T. is supported by an Medical Research Council grant (MR/S026088/1). S.R. is supported by the Austrian Science Foundation (FWF) grant I-3001. P.S. is supported by the Intramural Research Program of National Institute of Neurological Disorders and Stroke, National Institutes of Health. H.V. is supported by the Dutch multiple sclerosis Research Foundation, ZonMW and HealthHolland.
dc.format
application/pdf
dc.publisher
Oxford University Press
dc.relation
https://doi.org/10.1093/brain/awab029
dc.rights
Attribution-NonCommercial 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Esclerosi múltiple - Imatgeria per ressonància magnètica
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Imatgeria per al diagnòstic
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DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
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Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
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ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Neuroimaging
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ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
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Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
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TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::neuroimágenes
dc.title
Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
