Sistema de Salut de Catalunya
Institut Català de la Salut
[Santos García D, Cores C] Complexo Hospitalario Universitario de A Coruña, A Coruña, Spain. [de Deus Fonticoba T, Suárez Castro E] Complexo Hospitalario Universitario de Ferrol, A Coruña, Spain. [Hernández Vara J] Departament de Neurologia i Recerca de Malalties Neurodegeneratives. Campus Universitari de la Vall D'Hebron, Barcelona, Spain. [Jesús S, Mir P] Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, CSIC, CIBERNED, Universidad de Sevilla, Sevilla, Spain. [Solano Vila B] Institut d'Assistència Sanitària, Institut Català de la Salut, Salt, Spain
Institut d'Assistència Sanitària
2023-05-22T08:24:13Z
2023-05-22T08:24:13Z
2023-01-31
Malaltia de Parkinson; Levodopa; Factors de risc
Enfermedad de Parkinson; Levodopa; Factores de riesgo
Parkinson Disease; Levodopa; Risk Factors
Background:There is a need for identifying risk factors for hospitalization in Parkinson’s disease (PD) and also interventions to reduce acute hospital admission. Objective:To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort.Methods:PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit.Results:Thirty-five out of 605 (5.8%) PD patients (62.5±8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065–5.678; p = 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319–6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757–8.470; p = 0.001), and dysphagia (HR 2.356; 95% CI 1.124–4.941; p = 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080–8.322; p = 0.035) was an independent predictor of AH. Conclusion:Falls is an independent predictor of AH in PD patients
Article
Published version
English
Parkinson, Malaltia de; Dopa; Models de riscos proporcionals de Cox; DISEASES::Nervous System Diseases::Nervous System Diseases::Nervous System Diseases::Neurodegenerative Diseases::Parkinson Disease; CHEMICALS AND DRUGS::Organic Chemicals::Amines::Catecholamines::Dihydroxyphenylalanine::Levodopa; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models; ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson; COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::aminas::catecolaminas::dihidroxifenilalanina::levodopa; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::modelos estadísticos::modelos de riesgos proporcionales
IOS Press
Journal of Parkinson's Disease;13(1)
https://dx.doi.org/10.3233/JPD-212539
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
Articles científics - HVH [3440]
