dc.contributor
Institut Català de la Salut
dc.contributor
[Shinjo SK, Missé RG] Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. [Kim M] Center for Outcomes Research, Department of Internal Medicine, University of Illinois College of Medicine Peoria, Peoria, Illinois, USA. [Hoff LS] School of Medicine, Universidade Potiguar (UnP), Natal, Brazil. [Sen P] Maulana Azad Medical College, New Delhi, India. [Naveen R] Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. [O'Callaghan AS] Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Shinjo, Samuel
dc.contributor.author
Kim, Minchul
dc.contributor.author
Hoff, Leonardo
dc.contributor.author
Missé, Rafael Giovani
dc.contributor.author
Sen, Parikshit
dc.contributor.author
Naveen, R
dc.contributor.author
Selva-O'Callaghan, Albert
dc.date.accessioned
2025-10-24T10:38:43Z
dc.date.available
2025-10-24T10:38:43Z
dc.date.issued
2023-06-21T11:16:05Z
dc.date.issued
2023-06-21T11:16:05Z
dc.identifier
Shinjo SK, Kim M, Hoff LS, Missé RG, Sen P, Naveen R, et al. Pain in individuals with idiopathic inflammatory myopathies, other systemic autoimmune rheumatic diseases, and without rheumatic diseases: A report from the COVAD study. Int J Rheum Dis. 2023 Apr;26(4):727–39.
dc.identifier
https://hdl.handle.net/11351/9833
dc.identifier
10.1111/1756-185X.14636
dc.identifier
000950791600001
dc.identifier.uri
https://hdl.handle.net/11351/9833
dc.description.abstract
Myositis; Pain; Rheumatic diseases
dc.description.abstract
Miositis; Dolor; Enfermedades reumáticas
dc.description.abstract
Miositis; Dolor; Malalties reumàtiques
dc.description.abstract
Objectives
To compare pain intensity among individuals with idiopathic inflammatory myopathies (IIMs), other systemic autoimmune rheumatic diseases (AIRDs), and without rheumatic disease (wAIDs).
Methods
Data were collected from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study, an international cross-sectional online survey, from December 2020 to August 2021. Pain experienced in the preceding week was assessed using numeral rating scale (NRS). We performed a negative binomial regression analysis to assess pain in IIMs subtypes and whether demographics, disease activity, general health status, and physical function had an impact on pain scores.
Results
Of 6988 participants included, 15.1% had IIMs, 27.9% had other AIRDs, and 57.0% were wAIDs. The median pain NRS in patients with IIMs, other AIRDs, and wAIDs were 2.0 (interquartile range [IQR] = 1.0–5.0), 3.0 (IQR = 1.0–6.0), and 1.0 (IQR = 0–2.0), respectively (P < 0.001). Regression analysis adjusted for gender, age, and ethnicity revealed that overlap myositis and antisynthetase syndrome had the highest pain (NRS = 4.0, 95% CI = 3.5–4.5, and NRS = 3.6, 95% CI = 3.1–4.1, respectively). An additional association between pain and poor functional status was observed in all groups. Female gender was associated with higher pain scores in almost all scenarios. Increasing age was associated with higher pain NRS scores in some scenarios of disease activity, and Asian and Hispanic ethnicities had reduced pain scores in some functional status scenarios.
Conclusion
Patients with IIMs reported higher pain levels than wAIDs, but less than patients with other AIRDs. Pain is a disabling manifestation of IIMs and is associated with a poor functional status.
dc.description.abstract
HC is supported by the National Institution for Health Research Manchester Biomedical Research Centre Funding Scheme.
dc.format
application/pdf
dc.format
application/pdf
dc.relation
International Journal of Rheumatic Diseases;26(4)
dc.relation
https://doi.org/10.1111/1756-185X.14636
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Autoanticossos
dc.subject
Músculs - Inflamació
dc.subject
Malalties autoimmunitàries
dc.subject
COVID-19 (Malaltia)
dc.subject
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Myositis
dc.subject
DISEASES::Immune System Diseases::Autoimmune Diseases
dc.subject
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
dc.subject
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies
dc.subject
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositis
dc.subject
ENFERMEDADES::enfermedades del sistema inmune::enfermedades autoinmunes
dc.subject
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos
dc.title
Pain in individuals with idiopathic inflammatory myopathies, other systemic autoimmune rheumatic diseases, and without rheumatic diseases: A report from the COVAD study
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
