dc.contributor
[Riestra S] Gastroenterology Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain. [Taxonera C] Gastroenterology Department, Hospital Clínico Universitario San Carlos, Instituto de Investigación del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Zabana Y] Gastroenterology Department, Hospital Universitari Mútua Terrassa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Terrassa, Spain. [Carpio D] Gastroenterology Department, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain. [Chaparro M] Gastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain. [Barrio J] Gastroenterology Department, Hospital Universitario Río Hortega, Valladolid, Spain. [Piqueras M] Servei de Gastroenterologia, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain
dc.contributor
Consorci Sanitari de Terrassa
dc.contributor.author
Riestra Menéndez, Sabino
dc.contributor.author
Taxonera, Carlos
dc.contributor.author
Zabana, Yamile
dc.contributor.author
Carpio, Daniel
dc.contributor.author
Chaparro, María
dc.contributor.author
Barrio, Jesús
dc.contributor.author
PIQUERAS CANO, MARTA
dc.date.accessioned
2025-10-24T08:28:55Z
dc.date.available
2025-10-24T08:28:55Z
dc.date.issued
2023-06-22T11:57:48Z
dc.date.issued
2023-06-22T11:57:48Z
dc.date.issued
2022-07-05
dc.identifier
Riestra S, Taxonera C, Zabana Y, Carpio D, Chaparro M, Barrio J, et al. Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU. J Clin Med. 2022 Jul 5;11(13):3915.
dc.identifier
https://hdl.handle.net/11351/9860
dc.identifier
10.3390/jcm11133915
dc.identifier.uri
https://hdl.handle.net/11351/9860
dc.description.abstract
Inflammatory bowel disease; Interferon gamma release assays; Latent tuberculosis infection
dc.description.abstract
Enfermedad inflamatoria intestinal; Ensayos de liberación de interferón gamma; Infección tuberculosa latente
dc.description.abstract
Malaltia inflamatòria intestinal; Assajos d'alliberament gamma d'interferó; Infecció tuberculosa latent
dc.description.abstract
Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study evaluated the diagnostic performance of different LTBI screening strategies in patients with inflammatory bowel disease (IBD).
Methods: Patients in the Spanish ENEIDA registry with IBD screened for LTBI between January 2003 and January 2018 were included. The diagnostic yield of different strategies (dual screening with tuberculin skin test [TST] and interferon-ץ-release assay [IGRA], two-step TST, and early screening performed at least 12 months before starting biological treatment) was analyzed.
Results: Out of 7594 screened patients, 1445 (19%; 95% CI 18−20%) had LTBI. Immunomodulator (IMM) treatment at screening decreased the probability of detecting LTBI (20% vs. 17%, p = 0.001). Regarding screening strategies, LTBI was more frequently diagnosed by dual screening than by a single screening strategy (IGRA, OR 0.60; 95% CI 0.50−0.73, p < 0.001; TST, OR 0.76; 95% CI 0.66−0.88, p < 0.001). Two-step TST increased the diagnostic yield of a single TST by 24%. More cases of LTBI were diagnosed by early screening than by routine screening before starting anti-TNF agents (21% [95% CI 20−22%] vs. 14% [95% CI 13−16%], p < 0.001). The highest diagnostic performance for LTBI (29%) was obtained by combining early and TST/IGRA dual screening strategies in patients without IMM.
Conclusions: Both early screening and TST/IGRA dual screening strategies significantly increased diagnostic performance for LTBI in patients with IBD, with optimal performance achieved when they are used together in the absence of IMM.
dc.format
application/pdf
dc.relation
Journal of Clinical Medicine;11(13)
dc.relation
https://doi.org/10.3390/jcm11133915
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Intestins - Inflamació
dc.subject
DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Immunologic Tests::Interferon-gamma Release Tests
dc.subject
DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Actinomycetales Infections::Mycobacterium Infections::Tuberculosis::Latent Tuberculosis
dc.subject
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::pruebas inmunológicas::análisis de la liberación del interferón gamma
dc.subject
ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones por Actinomycetales::micobacteriosis::tuberculosis::tuberculosis latente
dc.title
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
