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RECERCAT Home > Universitat Internacional de Catalunya > Recerca > Articles > Ciències de la Salut > View document

To access the full text documents, please follow this link: http://hdl.handle.net/20.500.12328/1261

dc.contributor.author Barneda-Zahonero, Bruna
dc.contributor.author Miñano Molina, Alfredo Jesús
dc.contributor.author Badiola, Nahuai
dc.contributor.author Fadó Andrés, Rut
dc.contributor.author Xifró Collsamata, Xavier
dc.contributor.author Saura, Carlos A.
dc.contributor.author Rodríguez Álvarez, José
dc.date 2019-10-19T14:54:18Z
dc.date 2019-10-19T14:54:18Z
dc.date 2009-12-15
dc.identifier Barneda-Zahonero, B., Miñano-Molina, A., Badiola, N., Fadó, R., Xifró, X., Saura, C. A., & Rodríguez-Alvarez, J. (2009). «Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway». Molecular biology of the cell, 20(24), 5051-5063
dc.identifier 1059-1524
dc.identifier https://doi.org/10.1091/mbc.e09-05-0424
dc.identifier.uri http://hdl.handle.net/20.500.12328/1261
dc.description Bone morphogenetic proteins (BMPs) have been implicated in the generation and postnatal differentiation of cerebellar granule cells (CGCs). Here, we examined the eventual role of BMPs on the survival of these neurons. Lack of depolarization causes CGC death by apoptosis in vivo, a phenomenon that is mimicked in vitro by deprivation of high potassium in cultured CGCs. We have found that BMP-6, but not BMP-7, is able to block low potassium–mediated apoptosis in CGCs. The neuroprotective effect of BMP-6 is not accompanied by an increase of Smad translocation to the nucleus, suggesting that the canonical pathway is not involved. By contrast, activation of the MEK/ERK/CREB pathway by BMP-6 is necessary for its neuroprotective effect, which involves inhibition of caspase activity and an increase in Bcl-2 protein levels. Other pathways involved in the regulation of CGC survival, such as the c-Jun terminal kinase and the phosphatidylinositol 3-kinase (PI3K)-Akt/PKB, were not affected by BMP-6. Moreover, failure of BMP-7 to activate the MEK/ERK/CREB pathway could explain its inability to protect CGCs from low potassium–mediated apoptosis. Thus, this study demonstrates that BMP-6 acting through the noncanonical MEK/ERK/CREB pathway plays a crucial role on CGC survival.
dc.format 13
dc.format application/pdf
dc.language eng
dc.publisher Molecular biology of the cell
dc.rights https://creativecommons.org/licenses/by/4.0/
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject BMP
dc.subject protein
dc.subject proteina
dc.subject Cerebellar
dc.subject cerebral
dc.subject 616.8
dc.title Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/acceptedVersion

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