To access the full text documents, please follow this link: http://hdl.handle.net/20.500.12328/71

Title:	Use and misuse of PRP Clinical Trial Proposal to Help Find PRP’s True Efficacy
Author:	Mirallas, Oriol; Farelo, Javier; Grimalt Santacana, Ramon
Notes:	Since the early 1970s, Platelet-rich plasma (PRP) has been used in many fields as a potential remedy for having regenerative properties. In dermatology, its use is extended to different hair diseases: alopecia areata, traction alopecia, androgenetic alopecia (AGA), and even cicatricial alopecia. Despite its increasing use in the clinical practice, the protocol used to produce PRP differs greatly between researchers and its efficacy has not been clearly demonstrated. Particularly, AGA is an illness characterized by a progressive hair thinning and miniaturization caused by the effect of dihydrotestosterone (DHT) on the hair follicle. This type of alopecia is the most common in men, increasing its incidence with age. Until the date, there are only two efficient treatments approved by the FDA: Finasteride and Minoxidil. PRP seems to be a potential new candidate according to recent studies, but multiple PRP obtaining techniques have raised ambiguous results about the real efficacy of PRP in patients with AGA. Thus, we have elaborated a methodology to help researchers designing future clinical trials on PRP therapy. We propose a randomized clinical trial with a uniformed PRP obtaining technique in order to properly assess the PRP efficacy as a treatment for AGA. reprint
Subject(s):	-Male-pattern hair loss (MPHL) -Androgenetic alopecia (AGA) -Platelet-rich plasma (PRP) -Efficacy -Growth factors (GFs) -616.5
Rights:	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Document type:	Article
Share:

Show full item record