Coiled-coil conformation of a pentamidine-DNA complex

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To access the full text documents, please follow this link: http://hdl.handle.net/2117/8298

dc.contributor	Universitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.contributor	Universitat Politècnica de Catalunya. MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques
dc.contributor.author	Moreno Chicano, Tadeo
dc.contributor.author	Pous, Joan
dc.contributor.author	Subirana Torrent, Juan A.
dc.contributor.author	Campos López, Josefina de Lourdes
dc.date	2010-03
dc.identifier.citation	Moreno, T. [et al.]. Coiled-coil conformation of a pentamidine-DNA complex. "Acta crystallographica. Section D, biological crystallography", Març 2010, vol. 66, p. 251-257.
dc.identifier.citation	0907-4449
dc.identifier.citation	10.1107/S0907444909055693
dc.identifier.uri	http://hdl.handle.net/2117/8298
dc.language.iso	eng
dc.relation	http://www.ncbi.nlm.nih.gov/pubmed/20179336
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Enginyeria química
dc.subject	ADN -- Estructura
dc.subject	Genètica molecular
dc.title	Coiled-coil conformation of a pentamidine-DNA complex
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	The coiled-coil structure formed by the complex of the DNA duplex d(ATATATATAT)2 with pentamidine is presented. The duplex was found to have a mixed structure containing Watson-Crick and Hoogsteen base pairs. The drug stabilizes the coiled coil through the formation of cross-links between neighbouring duplexes. The central part of the drug is found in the minor groove as expected, whereas the charged terminal amidine groups protrude and interact with phosphates from neighbouring molecules. The formation of cross-links may be related to the biological effects of pentamidine, which is used as an antiprotozoal agent in trypanosomiasis, leishmaniasis and pneumonias associated with AIDS. The DNA sequence that was used is highly abundant in most eukaryotic genomes. However, very few data are available on DNA sequences which only contain A·T base pairs.

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