Osteogenic biphasic calcium sulphate dihydrate/iron-modified alpha-tricalcium phosphate bone cement for spinal applications : in vivo study

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dc.contributor	Universitat Politècnica de Catalunya. Departament de Mecànica de Fluids
dc.contributor	Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
dc.contributor	Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.contributor	Universitat Politècnica de Catalunya. GRICCA - Grup Interdepartamental per a la Col.laboració Científica Aplicada
dc.contributor.author	Vlad, María Daniela
dc.contributor.author	Sindilar, E.V.
dc.contributor.author	Mariñoso, Maria Lluïsa
dc.contributor.author	Poeata, I.
dc.contributor.author	Torres Cámara, Ricardo
dc.contributor.author	López López, José
dc.contributor.author	Barraco Serra, Marc
dc.contributor.author	Fernández Aguado, Enrique
dc.date	2010-02
dc.identifier.citation	Vlad, M. [et al.]. Osteogenic biphasic calcium sulphate dihydrate/iron-modified alpha-tricalcium phosphate bone cement for spinal applications : in vivo study. "Acta biomaterialia", Febrer 2010, vol. 6, núm. 2, p. 607-616.
dc.identifier.citation	1742-7061
dc.identifier.citation	10.1016/j.actbio.2009.07.010
dc.identifier.uri	http://hdl.handle.net/2117/19112
dc.language.iso	eng
dc.relation	http://www.sciencedirect.com/science/article/pii/S1742706109002979
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
dc.subject	Bone cements
dc.subject	Vertebroplasty
dc.subject	Calcium phosphate cement
dc.subject	Ciments ossis
dc.subject	Fosfat de calci
dc.subject	Vèrtebres -- Cirurgia
dc.title	Osteogenic biphasic calcium sulphate dihydrate/iron-modified alpha-tricalcium phosphate bone cement for spinal applications : in vivo study
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	Premi del "National University Research Council" del Ministeri d'Educació i Recerca de Romania, a autors romanesos per l'impacte de la seva recerca.
dc.description.abstract	In this study, the biocompatibility and the osteogenic features of a new iron-modified α-tricalcium phosphate (IM/α-TCP) and calcium sulphate dihydrate (CSD) biphasic cement (IM/α-TCP/CSD-BC) have been investigated in terms of the in vivo cement resorption, bone tissue formation and host tissue response on sheep animal model. Histological evaluation performed on undecalcified cement–bone specimens assessed the in vivo behaviour. It has been shown that the new IM/α-TCP/CSD-BC has the ability to produce firm bone binding in vivo (i.e. bioactivity). Qualitative histology proved cement biocompatibility, osteoconduction and favourable resorption, mainly through a macrophage-mediated mechanism. The results showed that the new cements have biocompatible and osteogenic features of interest as possible cancellous bone replacement biomaterial for minimally invasive spinal surgery applications.
dc.description.abstract	Peer Reviewed
dc.description.abstract	Award-winning

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