The smallest peptoids with antiproliferative activity on human neoplastic cells

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dc.contributor	Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.contributor.author	Mas Moruno, Carlos
dc.contributor.author	Cruz, Luis Javier
dc.contributor.author	Mora, P
dc.contributor.author	Francesch, A
dc.contributor.author	Messeguer, A
dc.contributor.author	Pérez-Payá, E
dc.contributor.author	Albericio, F
dc.date	2007
dc.identifier.citation	Mas-Moruno, C. [et al.]. The smallest peptoids with antiproliferative activity on human neoplastic cells. "Journal of medicinal chemistry", 2007, vol. 50, p. 2443-2449.
dc.identifier.citation	0022-2623
dc.identifier.citation	10.1021/jm061166z
dc.identifier.uri	http://hdl.handle.net/2117/22772
dc.language.iso	eng
dc.relation	http://pubs.acs.org/doi/abs/10.1021/jm061166z
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Enginyeria dels materials
dc.subject	Peptides
dc.subject	Pèptids
dc.title	The smallest peptoids with antiproliferative activity on human neoplastic cells
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	Libraries of new, small peptoid monomers and dipeptoids were synthesized and assayed for antiproliferative activity against representative human neoplastic cell lines. The C-terminal N-alkyl amide peptoids are cytotoxic and are the smallest peptoids reported to have such activity. These compounds were conveniently synthesized on a BAL resin. Owing to their structure, the peptoids did not suffer from DKP formation, a problematic side reaction typically observed in peptide and peptoid synthesis
dc.description.abstract	Peer Reviewed

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