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Título:	The role of connectivity and noise in the emergence of spontaneous activity in cultured neuronal networks
Autor/a:	Gomez Orlandi, Javier; Álvarez Lacalle, Enrique; Teller Amado, Sara; Casademunt Viader, Jaume; Soriano Fradera, Jordi
Otros autores:	Universitat Politècnica de Catalunya. Departament de Física; Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
Abstract:	Cultured neurons in vitro quickly connect to one another to establish a spontaneously active network within a week. The resulting neuronal network is char- acterized by a combination of excitatory and inhibitory integrate–and–fire units coupled through synaptic connec- tions, and that interact in a highly nonlinear manner. The nonlinear behavior emerges from the dynamics of both the neurons’ membrane potential and synaptic transmission, together with intrinsic biological noise. These ingredients give rise to a rich repertoire of phenomena that are still poorly understood, including periodic spontaneous activ- ity, avalanches, propagation of activity fronts, and synchro- nization. Here we describe some experimental results on spontaneous activity in cultures, and elaborate on theoreti- cal models that describe its initiation and maintenance
Abstract:	Peer Reviewed
Materia(s):	-Àrees temàtiques de la UPC::Enginyeria de la telecomunicació::Telemàtica i xarxes d'ordinadors -Neural networks (Computer science) -Xarxes neuronals (Informàtica) -- Aplicacions
Derechos:	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Tipo de documento:	Artículo - Versión publicada Artículo
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