Stainless steel possess better strength and stiffness reduction factors at high temperatures than carbon steel which has been shown to result in enhanced fire performance of structural components and assemblies. In recent years, a considerable amount of research has been devoted to the structural analysis and design of isolated stainless steel members at elevated temperatures. However, advances related to the behaviour of stainless steel frames subjected to fire are scarce. Actually, EN 1993-1-4 does not provide design rules for global analysis of stainless steel frames and EN 1993-1-2 provides a conservative approach for the fire design of stainless steel structures based on sparse test data. Therefore, experts have identified this particular topic as a priority for further research to assess the performance and the structural safety of stainless steel frames subjected to fire loads. The objective of this paper is to present a numerical modelling study on the behaviour of stainless steel frames under fire as an effort to identify the parameters governing their structural behaviour. In this study nonsway austenitic and ferritic stainless steel frames are analysed. The numerical model is validated against existing tests in the literature. Some considerations related to the analysis and design of stainless steel frames are pointed out based on the numerical results derived from the coupled thermo-mechanical model developed by using the FE software Abaqus.