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Título:	Validity of ICD-9 and ICD-10 codes used to identify acute liver injury: a study in three European data sources
Autor/a:	Forns, Joan; Cainzos Achirica, Miguel; Hellfritzsch, M; Morros Padrós, Rosa; Poblador Plou, Beatriz; Hallas, Jesper; Giner Soriano, Maria; Prados Torres, Alexandra; Pottegard, Anton; Cortés Martínez, Jordi; Castellsagué, Jordi; Jacquot, Emmanuelle; Deltour, Nicole; Pérez Gutthann, Susana; Pladevall, Miquel
Otros autores:	Universitat Politècnica de Catalunya. Doctorat en Estadística i Investigació Operativa; Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
Abstract:	This is the peer reviewed version of the following article: Forns, J. [et al.]. Validity of ICD-9 and ICD-10 codes used to identify acute liver injury: a study in three European data sources. "Pharmacoepidemiology and drug safety", 6 Juny 2019, vol. 28, núm. 7, p. 965-975, which has been published in final form at 10.1002/pds.4803. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
Abstract:	Purpose Validating cases of acute liver injury (ALI) in health care data sources is challenging. Previous validation studies reported low positive predictive values (PPVs). Methods Case validation was undertaken in a study conducted from 2009 to 2014 assessing the risk of ALI in antidepressants users in databases in Spain (EpiChron and SIDIAP) and the Danish National Health Registers. Three ALI definitions were evaluated: primary (specific hospital discharge codes), secondary (specific and nonspecific hospital discharge codes), and tertiary (specific and nonspecific hospital and outpatient codes). The validation included review of patient profiles (EpiChron and SIDIAP) and of clinical data from medical records (EpiChron and Denmark). ALI cases were confirmed when liver enzyme values met a definition by an international working group. Results Overall PPVs (95% CIs) for the study ALI definitions were, for the primary ALI definition, 84% (60%-97%) (EpiChron), 60% (26%-88%) (SIDIAP), and 74% (60%-85%) (Denmark); for the secondary ALI definition, 65% (45%-81%) (EpiChron), 40% (19%-64%) (SIDIAP), and 70% (64%-77%) (Denmark); and for the tertiary ALI definition, 25% (18%-34%) (EpiChron), 8% (7%-9%) (SIDIAP), and 47% (42%-52%) (Denmark). The overall PPVs were higher for specific than for nonspecific codes and for hospital discharge than for outpatient codes. The nonspecific code “unspecified jaundice” had high PPVs in Denmark. Conclusions PPVs obtained apply to patients using antidepressants without preexisting liver disease or ALI risk factors. To maximize validity, studies on ALI should prioritize hospital specific discharge codes and should include hospital codes for unspecified jaundice. Case validation is required when ALI outpatient cases are considered.
Abstract:	Peer Reviewed
Materia(s):	-Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària -Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant -Biomathematics -Sampling (Statistics) -acute liver -injury -antidepressants -pharmacoepidemiology validation -Biomatemàtica -Mostreig (Estadística) -Classificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general -Classificació AMS::62 Statistics::62D05 Sampling theory, sample surveys
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Tipo de documento:	Artículo - Versión presentada Artículo
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