Universitat Autònoma de Barcelona
Altres ajuts: This work was supported by grants from Consejo de Seguridad Nuclear (CSN 2012-0001) and EURATOM (Dark.Risk GA 323216) to AG
Aging involves a deterioration of cell functions and changes that may predispose the cell to undergo an oncogenic transformation. The carcinogenic risks following radiation exposure rise with age among adults. Increasing inflammatory response, loss of oxidant/antioxidant equilibrium, ongoing telomere attrition, decline in the DNA damage response efficiency, and deleterious nuclear organization are age-related cellular changes that trigger a serious threat to genomic integrity. In this review, we discuss the mechanistic interplay between all these factors, providing an integrated view of how they contribute to the observed age-related increase in radiation sensitivity. As life expectancy increases and so it does the medical intervention, it is important to highlight the benefits of radiation protection in the elderly. Thus, a deep understanding of the mechanistic processes confining the threat of aging-related radiosensitivity is currently of foremost relevance.
English
Chromatin organization; DNA repair; Nuclear envelope; Oxidative stress; Replicative senescence; Radiosensitivity
Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-524
Instituto de Salud Carlos III CP13/00160
Ministerio de Economía y Competitividad SAF2013-43801-P
Aging Cell ; Vol. 14, Issue 2 (April 2015), p. 153-161
open access
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