Neurodevelopmental risk copy number variants in adults with intellectual disabilities and comorbid psychiatric disorders

Abstract

Copy number variants (CNVs) are established risk factors for neurodevelopmental disorders. To date the study of CNVs in psychiatric illness has focused on single disorder populations. The role of CNVs in individuals with intellectual disabilities and psychiatric comorbidities are less well characterised. To determine the type and frequency of CNVs in adults with intellectual disabilities and comorbid psychiatric disorders. A chromosomal microarray analysis of 599 adults recruited from intellectual disabilities psychiatry services at three European sites. The yield of pathogenic CNVs was high - 13%. Focusing on established neurodevelopmental disorder risk loci we find a significantly higher frequency in individuals with intellectual disabilities and comorbid psychiatric disorder (10%) compared with healthy controls (1.2%, P <0.0001), schizophrenia (3.1%, P <0.0001) and intellectual disability/autism spectrum disorder (6.5%, P < 0.00084) populations. In the largest sample of adults with intellectual disabilities and comorbid psychiatric disorders to date, we find a high rate of pathogenic CNVs. This has clinical implications for the use of genetic investigations in intellectual disability psychiatry. None.