dc.contributor.author |
Portillo, Karina |
dc.contributor.author |
Torralba, Yolanda |
dc.contributor.author |
Blanco, Isabel |
dc.contributor.author |
Burgos, Felip |
dc.contributor.author |
Rodríguez-Roisin, Robert |
dc.contributor.author |
Rios, Jose |
dc.contributor.author |
Roca, Josep |
dc.contributor.author |
Barberà i Mir, Joan Albert |
dc.date |
2015 |
dc.identifier |
https://ddd.uab.cat/record/185382 |
dc.identifier |
urn:10.2147/COPD.S78180 |
dc.identifier |
urn:oai:ddd.uab.cat:185382 |
dc.identifier |
urn:pmid:26203238 |
dc.identifier |
urn:pmcid:PMC4507485 |
dc.identifier |
urn:pmc-uid:4507485 |
dc.identifier |
urn:articleid:11782005v10p1313 |
dc.identifier |
urn:scopus_id:84937561966 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:4507485 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/8988ab5c-1f42-4f37-a7ac-2203de7f4130 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Instituto de Salud Carlos III EC07-90049 |
dc.relation |
International journal of COPD ; Vol. 10 (july 2015), p. 1313-1320 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by-nc/4.0/ |
dc.subject |
Pulmonary hypertension |
dc.subject |
Right heart catheterization |
dc.subject |
Cardiac index |
dc.subject |
GOLD |
dc.title |
Pulmonary hemodynamic profile in chronic obstructive pulmonary disease |
dc.type |
Article |
dc.description.abstract |
Few data are available in regards to the prevalence of pulmonary hypertension (PH) in the broad spectrum of COPD. This study was aimed at assessing the prevalence of PH in a cohort of COPD patients across the severity of airflow limitation, and reporting the hemodynamic characteristics at rest and during exercise. We performed a retrospective analysis on COPD patients who underwent right-heart catheterization in our center with measurements obtained at rest (n=139) and during exercise (n=85). PH was defined as mean pulmonary artery pressure (mPAP) ≥25 mmHg and pulmonary capillary wedge pressure <15 mmHg. Exercise-induced PH (EIPH) was defined by a ratio of ΔmPAP/Δcardiac output >3. PH was present in 25 patients (18%). According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification, PH prevalence in GOLD 2 was 7% (3 patients); 25% (14 patients) in GOLD 3; and 22% (8 patients) in GOLD 4. Severe PH (mPAP ≥35 mmHg) was identified in four patients (2.8%). Arterial partial oxygen pressure was the outcome most strongly associated with PH (r =−0.29, P <0.001). EIPH was observed in 60 patients (71%) and had a similar prevalence in both GOLD 2 and 3, and was present in all GOLD 4 patients. Patients with PH had lower cardiac index during exercise than patients without PH (5.0±1.2 versus 6.7±1.4 L/min/m 2, respectively; P =0.001). PH has a similar prevalence in COPD patients with severe and very-severe airflow limitation, being associated with the presence of arterial hypoxemia. In contrast, EIPH is highly prevalent, even in moderate COPD, and might contribute to limiting exercise tolerance. |