In this paper, we propose a description of the Rashba-Dresselhaus effect in Hybrid Organic Perovskite (HOP). We show how the loss of the inversion symmetry leads to the loss of the spin degeneracy. An example of structure where both Rashba and Dresselhaus operate is illustrated with the formamidinium tin iodide CH(NH)SnI. The control of this effect is as well addressed by two examples. A first example concerns the control with the temperature and is demonstrated for the 2D HOP BzPbCl (Bz = benzylammonium). Then the control with an external field is established for the 3D HOP CHNHPbBr.