dc.contributor.author |
Castaño-Núñez, Ángel |
dc.contributor.author |
Montes-Cano, Marco-Antonio |
dc.contributor.author |
García-Lozano, José-Raúl |
dc.contributor.author |
Ortego-Centeno, Norberto |
dc.contributor.author |
García-Hernández, Francisco-José |
dc.contributor.author |
Espinosa, Gerard |
dc.contributor.author |
Graña-Gil, Genaro. |
dc.contributor.author |
Sánchez-Bursón, Juan |
dc.contributor.author |
Juliá, María Rosa |
dc.contributor.author |
Solans, Roser |
dc.contributor.author |
Blanco, Ricardo |
dc.contributor.author |
Barnosi-Marín, Ana-Celia |
dc.contributor.author |
Gómez de la Torre, Ricardo |
dc.contributor.author |
Fanlo, Patricia |
dc.contributor.author |
Rodríguez-Carballeira, Mónica |
dc.contributor.author |
Rodriguez-Rodriguez, Luis |
dc.contributor.author |
Camps i Miró, Teresa |
dc.contributor.author |
Castañeda, Santos |
dc.contributor.author |
Alegre-Sancho, Juan José |
dc.contributor.author |
Martín, Javier |
dc.contributor.author |
González-Escribano, María Francisca |
dc.contributor.author |
Universidad Autònoma de Barcelona |
dc.date |
2019 |
dc.identifier |
https://ddd.uab.cat/record/223419 |
dc.identifier |
urn:10.3389/fimmu.2019.02755 |
dc.identifier |
urn:oai:ddd.uab.cat:223419 |
dc.identifier |
urn:scopus_id:85076837491 |
dc.identifier |
urn:articleid:16643224v10p2755 |
dc.identifier |
urn:pmid:31849952 |
dc.identifier |
urn:pmc-uid:6896819 |
dc.identifier |
urn:pmcid:PMC6896819 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:6896819 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Instituto de Salud Carlos III 16/01373 |
dc.relation |
Instituto de Salud Carlos III 13/01118 |
dc.relation |
Frontiers in immunology ; Vol. 10 (29 2019), p. 2755 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Behçet's disease |
dc.subject |
HLA |
dc.subject |
KIR |
dc.subject |
NK cells |
dc.subject |
Functional polymorphisms |
dc.title |
Association of Functional Polymorphisms of KIR3DL1/DS1 With Behçet's Disease |
dc.type |
Article |
dc.description.abstract |
Behçet's disease (BD) is an immune-mediated vasculitis related to imbalances between the innate and adaptive immune response. Infectious agents or environmental factors may trigger the disease in genetically predisposed individuals. HLA-B51 is the genetic factor stronger associated with the disease, although the bases of this association remain elusive. NK cells have also been implicated in the etiopathogenesis of BD. A family of NK receptors, Killer-cell Immunoglobulin-like Receptor (KIR), with a very complex organization, is very important in the education and control of the NK cells by the union to their ligands, most of them, HLA class I molecules. This study aimed to investigate the contribution of certain KIR functional polymorphisms to the susceptibility to BD. A total of 466 BD patients and 444 healthy individuals were genotyped in HLA class I (A, B, and C). The set of KIR genes and the functional variants of KIR3DL1/DS1 and KIR2DS4 were also determined. Frequency of KIR3DL1004 was lower in patients than in controls (0.15 vs. 0.20, P = 0.005, Pc = 0.015; OR = 0.70; 95% CI 0.54-0.90) in both B51 positive and negative individuals. KIR3DL1004, which encodes a misfolded protein, is included in a common telomeric haplotype with only one functional KIR gene, KIR3DL2. Both, KIR3DL1 and KIR3DL2 sense pathogen-associated molecular patterns but they have different capacities to eliminate them. The education of the NK cells depending on the HLA, the balance of KIR3DL1/KIR3DL2 licensed NK cells and the different capacities of these receptors to eliminate pathogens could be involved in the etiopathogenesis of BD. |