dc.contributor.author |
Papandreou, Christopher |
dc.contributor.author |
Li, Jun |
dc.contributor.author |
Liang, Liming |
dc.contributor.author |
Bulló, Mònica |
dc.contributor.author |
Zheng, Yan |
dc.contributor.author |
Ruiz-Canela, Miguel |
dc.contributor.author |
Yu, Edward |
dc.contributor.author |
Guasch-Ferré, Marta |
dc.contributor.author |
Razquin, Cristina |
dc.contributor.author |
Clish, Clary |
dc.contributor.author |
Corella, Dolores |
dc.contributor.author |
Estruch, Ramón |
dc.contributor.author |
Ros, Emilio |
dc.contributor.author |
Fitó, Montserrat |
dc.contributor.author |
Arós, Fernando |
dc.contributor.author |
Serra-Majem, Lluís |
dc.contributor.author |
Rosique, Nuria |
dc.contributor.author |
Martínez-González, Miguel A. |
dc.contributor.author |
Hu, Frank B. |
dc.contributor.author |
Salas-Salvadó, Jordi |
dc.contributor.author |
Universitat Autònoma de Barcelona |
dc.date |
2019 |
dc.identifier |
https://ddd.uab.cat/record/223695 |
dc.identifier |
urn:10.1038/s41598-019-39441-6 |
dc.identifier |
urn:oai:ddd.uab.cat:223695 |
dc.identifier |
urn:pmid:30814579 |
dc.identifier |
urn:scopus_id:85062293680 |
dc.identifier |
urn:articleid:20452322v9n1p2892 |
dc.identifier |
urn:pmc-uid:6393542 |
dc.identifier |
urn:pmcid:PMC6393542 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:6393542 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Instituto de Salud Carlos III G03-140 |
dc.relation |
Instituto de Salud Carlos III RD06-0045 |
dc.relation |
Instituto de Salud Carlos III CNIC06-2007 |
dc.relation |
Instituto de Salud Carlos III PI04-2239 |
dc.relation |
Instituto de Salud Carlos III PI05-2584 |
dc.relation |
Instituto de Salud Carlos III CP06-00100 |
dc.relation |
Instituto de Salud Carlos III PI07-0240 |
dc.relation |
Instituto de Salud Carlos III PI07-1138 |
dc.relation |
Instituto de Salud Carlos III PI07-0954 |
dc.relation |
Instituto de Salud Carlos III PI07-0473 |
dc.relation |
Instituto de Salud Carlos III PI10-01407 |
dc.relation |
Instituto de Salud Carlos III PI10-02658 |
dc.relation |
Instituto de Salud Carlos III PI11-01647 |
dc.relation |
Instituto de Salud Carlos III P11-02505 |
dc.relation |
Instituto de Salud Carlos III PI13-00462 |
dc.relation |
Ministerio de Ciencia e Innovación AGL-2009-13906-C02 |
dc.relation |
Ministerio de Ciencia e Innovación AGL2010-22319-C03 |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca SLT002-0016-00428 |
dc.relation |
Scientific reports ; Vol. 9 Núm. 1 (january 2019), p. 2892 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.title |
Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism |
dc.type |
Article |
dc.description.abstract |
Altres ajuts: Fundació La Marató de TV3 538/U/2016. |
dc.description.abstract |
Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated. |