Title:
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Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly
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Author:
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Pegueroles, Jordi; Pané, Adriana; Vilaplana, Eduard; Montal, Victor; Bejanin, Alexandre; Videla Toro, Laura; Carmona Iragui, María; Barroeta, Isabel; Ibarzabal, Ainitze; Casajoana, Anna; Alcolea, Daniel; Valldeneu, Silvia; Altuna-Azkargorta, Miren; de Hollanda, Ana; Vidal, Josep; Ortega, Emilio; Osorio, Ricardo; Convit, Antonio; Blesa, Rafael; Lleó, Alberto; Fortea, Juan; Jiménez, Amanda; Universitat Autònoma de Barcelona
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Abstract:
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Altres ajuts: This study was supported by the CIBERNED program (Program 1, Alzheimer Disease SIGNAL study, www.signalstudy.es); and partly jointly funded by Fondo Europeo de Desarrollo Regional, Unión Europea, Una manera de hacer Europa. This work was also supported by the National Institutes of Health (NIA grants 1R01AG056850 - 01A1; R21AG056974, and R01AG061566), Fundació La Marató de TV3 (20141210, 044412). This work was also supported by the Fundació Bancaria La Caixa."Ajut a la Recerca Josep Font" (Hospital Clinic de Barcelona). Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). [...]. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). |
Abstract:
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Midlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly. We selected controls from ADNI2 with CSF AD biomarkers and/or fluorodeoxyglucose positron emission tomography (FDG-PET) and 3T-MRI. We measured cortical thickness, FDG uptake, and CSF amyloid beta (Aβ)1-42, p-tau, and t-tau levels. We performed regression analyses between these biomarkers and body mass index (BMI). We included 201 individuals (mean age 73.5 years, mean BMI 27.4 kg/m 2). Higher BMI was related to less cortical thickness and higher metabolism in brain areas typically not involved in AD (family-wise error [FWE] <0.05), but not to AD CSF biomarkers. It is notable that the impact of obesity on brain metabolism and structure was also found in amyloid negative individuals. In the cognitively unimpaired elderly, obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology. |
Subject(s):
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-Body mass index -Cerebrospinal fluid Alzheimer's disease biomarkers -Fluorodeoxyglucose PET -Magnetic resonance imaging -Obesity -Pre-clinical Alzheimer's disease |
Rights:
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open access
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Document type:
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Article |
Published by:
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Share:
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Uri:
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https://ddd.uab.cat/record/231232
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