Título:
|
Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study
|
Autor/a:
|
Engelkes, Marjolein; Baan, Esme J.; de Ridder, Maria A. J.; Svensson, Elisabeth; Prieto-Alhambra, Daniel; Lapi, Francesco; Giaquinto, Carlo; Picelli, Gino; Boudiaf, Nada; Albers, Frank; Evitt, Lee A.; Cockle, Sarah; Bradford, Eric; Van Dyke, Melissa K.; Suruki, Robert; Rijnbeek, Peter; Sturkenboom, Miriam C. J. M.; Janssens, Hettie M.; Verhamme, Katia M. C.; Universitat Autònoma de Barcelona
|
Abstract:
|
Altres ajuts: This trial was funded by Eli Lilly and Company. |
Abstract:
|
There are sparse real-world data on severe asthma exacerbations (SAE) in children. This multinational cohort study assessed the incidence of and risk factors for SAE and the incidence of asthma-related rehospitalization in children with asthma. Asthma patients 5-17 years old with ≥1 year of follow-up were identified in six European electronic databases from the Netherlands, Italy, the UK, Denmark and Spain in 2008-2013. Asthma was defined as ≥1 asthma-specific disease code within 3 months of prescriptions/dispensing of asthma medication. Severe asthma was defined as high-dosed inhaled corticosteroids plus a second controller. SAE was defined by systemic corticosteroids, emergency department visit and/or hospitalization all for reason of asthma. Risk factors for SAE were estimated by Poisson regression analyses. The cohort consisted of 212 060 paediatric asthma patients contributing to 678 625 patient-years (PY). SAE rates ranged between 17 and 198/1000 PY and were higher in severe asthma and highest in severe asthma patients with a history of exacerbations. Prior SAE (incidence rate ratio 3-45) and younger age increased the SAE risk in all countries, whereas obesity, atopy and GERD were a risk factor in some but not all countries. Rehospitalization rates were up to 79% within 1 year. In a real-world setting, SAE rates were highest in children with severe asthma with a history of exacerbations. Many severe asthma patients were rehospitalized within 1 year. Asthma management focusing on prevention of SAE is important to reduce the burden of asthma. |
Materia(s):
|
-Asthma: epidemiology -Asthma: risk factors -Epidemiology: prevalence |
Derechos:
|
open access
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
https://creativecommons.org/licenses/by/4.0/ |
Tipo de documento:
|
Article |
Editor:
|
|
Compartir:
|
|
Uri:
|
https://ddd.uab.cat/record/232703
|