Context: The emergence of COVID-19 caused a new public health crisis, leading to major changes in daily life routines, often including physical activity (PA) levels. The main goal of this study was to analyze the differences in self-reported physical activity of people with complete spinal cord injuries between the time prior to the COVID-19 lockdown and the lockdown period itself. Methods: A sample of 20 participants with complete thoracic spinal cord injuries completed the Physical Activity Scale for Individuals with Physical Disabilities before and during the COVID-19 lockdown. Results: The results showed differences between the pre-lockdown and lockdown measurements in total selfreported PA (z=−3.92; P<0.001; d=1.28), recreational PA (z=−3.92; P<0.001; d=1.18) and occupational PA (z=−2.03; P=0.042; d=0.55). Nevertheless, no differences were found in housework PA between the two time periods. Furthermore, the results showed differences in total minutes (z=−3.92; P<0.001; d=1.75), minutes spent on recreational activities (z=−3.82; P<0.001; d=1.56) and minutes spent on occupational activities (z=−2.032; P=0.042; d=0.55) of moderate/vigorous intensity. Conclusions: Individuals with thoracic spinal cord injuries who were full-time manual wheelchair users displayed lower levels of PA during the pandemic than in the pre-pandemic period. The results suggest that the prohibition and restrictions on carrying out recreational and/or occupational activities are the main reasons for this inactivity. Physical activity promotion strategies should be implemented within this population to lessen the effects of this physical inactivity stemming from the COVID-19 pandemic.