dc.contributor.author |
Rudenick, Paula A. |
dc.contributor.author |
Bijnens, Bart H. |
dc.contributor.author |
Segers, Patrick |
dc.contributor.author |
García-Dorado, David |
dc.contributor.author |
Evangelista Masip, Arturo |
dc.contributor.author |
Universitat Autònoma de Barcelona |
dc.date |
2015 |
dc.date.accessioned |
2022-10-31T08:10:23Z |
dc.date.available |
2022-10-31T08:10:23Z |
dc.date.issued |
2022-10-31 |
dc.identifier |
https://ddd.uab.cat/record/254348 |
dc.identifier |
urn:10.1371/journal.pone.0124011 |
dc.identifier |
urn:oai:ddd.uab.cat:254348 |
dc.identifier |
urn:pmcid:PMC4399844 |
dc.identifier |
urn:pmc-uid:4399844 |
dc.identifier |
urn:pmid:25881158 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:4399844 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/6f25af7e-84c4-44bf-81cd-a55fd405a22b |
dc.identifier |
urn:scopus_id:84928138046 |
dc.identifier.uri |
http://hdl.handle.net/2072/526092 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Instituto de Salud Carlos III PI108/0608 |
dc.relation |
Instituto de Salud Carlos III PI11/01709 |
dc.relation |
PloS one ; Vol. 10 (april 2015) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.title |
Assessment of Wall Elasticity Variations on Intraluminal Haemodynamics in Descending Aortic Dissections Using a Lumped-Parameter Model |
dc.type |
Article |
dc.description.abstract |
Descending aortic dissection (DAD) is associated with high morbidity and mortality rates. Aortic wall stiffness is a variable often altered in DAD patients and potentially involved in long-term outcome. However, its relevance is still mostly unknown. To gain more detailed knowledge of how wall elasticity (compliance) might influence intraluminal haemodynamics in DAD, a lumped-parameter model was developed based on experimental data from a pulsatile hydraulic circuit and validated for 8 clinical scenarios. Next, the variations of intraluminal pressures and flows were assessed as a function of wall elasticity. In comparison with the most rigid-wall case, an increase in elasticity to physiological values was associated with a decrease in systolic and increase in diastolic pressures of up to 33% and 63% respectively, with a subsequent decrease in the pressure wave amplitude of up to 86%. Moreover, it was related to an increase in multidirectional intraluminal flows and transition of behaviour as 2 parallel vessels towards a vessel with a side-chamber. The model supports the extremely important role of wall elasticity as determinant of intraluminal pressures and flow patterns for DAD, and thus, the relevance of considering it during clinical assessment and computational modelling of the disease |