dc.contributor.author |
Vara González, Covadonga |
dc.contributor.author |
Paytuví-Gallart, Andreu |
dc.contributor.author |
Cuartero, Yasmina |
dc.contributor.author |
Álvarez-González, Lucía |
dc.contributor.author |
Marin Gual, Laia |
dc.contributor.author |
García, Francisca |
dc.contributor.author |
Florit-Sabater, Beatriu |
dc.contributor.author |
Capilla, Laia |
dc.contributor.author |
Sanchéz-Guillén, Rosa Ana |
dc.contributor.author |
Sarrate Navas, Zaida |
dc.contributor.author |
Aiese Cigliano, Riccardo |
dc.contributor.author |
Sanseverino, Walter |
dc.contributor.author |
Searle, Jeremy B. |
dc.contributor.author |
Ventura Queija, Jacinto |
dc.contributor.author |
Marti-Renom, Marc A. |
dc.contributor.author |
Le Dily, François |
dc.contributor.author |
Ruiz-Herrera Moreno, Aurora |
dc.date |
2021 |
dc.identifier |
https://ddd.uab.cat/record/255585 |
dc.identifier |
urn:10.1038/s41467-021-23270-1 |
dc.identifier |
urn:oai:ddd.uab.cat:255585 |
dc.identifier |
urn:pmcid:PMC8137915 |
dc.identifier |
urn:pmc-uid:8137915 |
dc.identifier |
urn:pmid:34016985 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:8137915 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/10947199-7929-477b-944c-d8fee7b32ae3 |
dc.identifier |
urn:scopus_id:85106343758 |
dc.identifier |
urn:wos_id:000658760700004 |
dc.identifier |
urn:articleid:20411723v12p2981 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Ministerio de Economía y Competitividad CGL2014-54317-P |
dc.relation |
Agencia Estatal de Investigación CGL2017-83802-P |
dc.relation |
Ministerio de Economía y Competitividad BFU2013-47736-P |
dc.relation |
Agencia Estatal de Investigación BFU2017-85926-P |
dc.relation |
Ministerio de Ciencia e Innovación CGL2010-15243 |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca DI-2015 |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca SGR-1215 |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca SGR-468 |
dc.relation |
Ministerio de Economía y Competitividad BES-2015-072924 |
dc.relation |
Ministerio de Economía y Competitividad PRE-2018-083257 |
dc.relation |
Ministerio de Ciencia e Innovación FPU18/03867 |
dc.relation |
European Commission 609989 |
dc.relation |
European Commission 676556 |
dc.relation |
Ministerio de Economía y Competitividad BFU2015-71786-REDT |
dc.relation |
Nature communications ; Vol. 12 (May 2021), art. 2981 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Chromosomes |
dc.subject |
Genome |
dc.title |
The impact of chromosomal fusions on 3D genome folding and recombination in the germ line |
dc.type |
Article |
dc.description.abstract |
The spatial folding of chromosomes inside the nucleus has regulatory effects on gene expression, yet the impact of genome reshuffling on this organization remains unclear. Here, we take advantage of chromosome conformation capture in combination with single-nucleotide polymorphism (SNP) genotyping and analysis of crossover events to study how the higher-order chromatin organization and recombination landscapes are affected by chromosomal fusions in the mammalian germ line. We demonstrate that chromosomal fusions alter the nuclear architecture during meiosis, including an increased rate of heterologous interactions in primary spermatocytes, and alterations in both chromosome synapsis and axis length. These disturbances in topology were associated with changes in genomic landscapes of recombination, resulting in detectable genomic footprints. Overall, we show that chromosomal fusions impact the dynamic genome topology of germ cells in two ways: (i) altering chromosomal nuclear occupancy and synapsis, and (ii) reshaping landscapes of recombination. |