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Multi-modal and multi-model interrogation of large-scale functional brain networks 

Castaldo, Francesca; Páscoa dos Santos, Francisco; Timms, Ryan C.; Cabral, Joana; Vohryzek, Jakub; Deco, Gustavo; Woolrich, Mark W.; Friston, Karl; Verschure, Paul F. M. J.; Litvak, Vladimir (Publication date: 2026-03-09)

Existing whole-brain models are generally tailored to the modelling of a particular data modality (e.g., fMRI or MEG/EEG). We propose that despite the differing aspects of neural activity each modality captures, they ...

Barriers and facilitators impacting the implementation of digital interventions targeted at mental health and musculoskeletal disorders in the workplace: a scoping review protocol 

Leduc, Mallorie; Guinart, Daniel; PROSPERH Consortium (Publication date: 2026-03-09)

Background: The digital transition in the workplace has increased trends such as permanent connectivity, an increased sedentary lifestyle, and reduced social interaction, leading to additional psychosocial and ergonomic ...

Metastable oscillatory modes as a signature of entropy management in the brain 

Xavier, Marta; Figueiredo, Patrícia; Deco, Gustavo; Luppi, Andrea I.; Cabral, Joana (Publication date: 2026-03-09)

Entropy management, central to the Free Energy Principle, requires a process that temporarily shifts brain activity toward states of lower or higher entropy. Metastable synchronization is a process by which a system achieves ...

The Thermodynamics of Mind 

Kringelbach, Morten L.; Sanz Perl, Yonatan; Deco, Gustavo (Publication date: 2026-03-09)

To not only survive, but also thrive, the brain must efficiently orchestrate distributed computation across space and time. This requires hierarchical organisation facilitating fast information transfer and processing at ...

Selective brain activations and connectivities related to the storage and recall of human object-location, reward-location, and word-pair episodic memories 

Rolls, Edmund T.; Zhang, Ruohan; Deco, Gustavo; Vatansever, Deniz; Feng, Jianfeng (Publication date: 2026-03-09)

Different cortical systems to the hippocampus were activated using fMRI during different types of episodic memory task. For object with scene location episodic memory, the activations were high in cortical systems involved ...

Beyond focal lesions: dynamical network effects of white matter hyperintensities 

Leone, Ricardo; Geysen, Steven; Deco, Gustavo; Kobeleva, Xenia (Publication date: 2026-03-09)

White matter (WM) tracts shape the brain's dynamical activity and their damage (e.g., white matter hyperintensities, WMH) yields relevant functional alterations, ultimately leading to cognitive symptoms. The mechanisms ...

One ring to rule them all: the unifying role of prefrontal cortex in steering task-related brain dynamics 

Deco, Gustavo; Sanz Perl, Yonatan; Ponce-Alvarez, Adrián; Tagliazucchi, Enzo; Whybrow, Peter C.; Fuster, Joaquín; Kringelbach, Morten L. (Publication date: 2026-03-09)

Surviving and thriving in a complex world require intricate balancing of higher order brain functions with essential survival-related behaviours. Exactly how this is achieved is not fully understood but a large body of ...

Brain dynamics predictive of response to psilocybin for treatment-resistant depression 

Vohryzek, Jakub; Cabral, Joana; Lord, Louis-David; Fernandes, Henrique M.; Roseman, Leor; Nutt, David J.; Carhart-Harris, Robin L; Deco, Gustavo; Kringelbach, Morten L. (Publication date: 2026-03-09)

Psilocybin therapy for depression has started to show promise, yet the underlying causal mechanisms are not currently known. Here, we leveraged the differential outcome in responders and non-responders to psilocybin (10 ...

A view-based decision mechanism for rewards in the primate amygdala 

Grabenhorst, Fabian; Ponce-Alvarez, Adrián; Battaglia-Mayer, Alexandra; Deco, Gustavo; Schultz, Wolfram (Publication date: 2026-03-09)

Primates make decisions visually by shifting their view from one object to the next, comparing values between objects, and choosing the best reward, even before acting. Here, we show that when monkeys make value-guided ...

The impact of regional heterogeneity in whole-brain dynamics in the presence of oscillations 

Sanz Perl, Yonatan; Zamora-López, Gorka; Montbrió, Ernest, 1974-; Monge-Asensio, Martí; Vohryzek, Jakub; Fittipaldi, Sol; Gonzalez Campo, Cecilia; Moguilner, Sebastián; Ibañez, Agustin; Tagliazucchi, Enzo; Yeo, B. T. Thomas; Kringelbach, Morten L.; Deco, Gustavo (Publication date: 2026-03-09)

Large variability exists across brain regions in health and disease, considering their cellular and molecular composition, connectivity, and function. Large-scale whole-brain models comprising coupled brain regions provide ...

A low dimensional embedding of brain dynamics enhances diagnostic accuracy and behavioral prediction in stroke 

Idesis, Sebastian Ariel; Allegra, Michele; Vohryzek, Jakub; Sanz Perl, Yonatan; Faskowitz, Joshua; Sporns, Olaf; Corbetta, Maurizio; Deco, Gustavo (Publication date: 2026-03-09)

Large-scale brain networks reveal structural connections as well as functional synchronization between distinct regions of the brain. The latter, referred to as functional connectivity (FC), can be derived from neuroimaging ...

Computational modelling in disorders of consciousness: closing the gap towards personalised models for restoring consciousness 

Luppi, Andrea I.; Cabral, Joana; Cofre, Rodrigo; Mediano, Pedro A.M.; Rosas, Fernando E; Qureshi, Abid Y.; Kuceyeski, Amy; Tagliazucchi, Enzo; Raimondo, Federico; Deco, Gustavo; Shine, James M; Kringelbach, Morten L.; Orio, Patricio; Ching, ShiNung; Sanz Perl, Yonatan; Diringer, Michael N.; Stevens, Robert D.; Sitt, Jacobo Diego (Publication date: 2026-03-09)

Disorders of consciousness are complex conditions characterised by persistent loss of responsiveness due to brain injury. They present diagnostic challenges and limited options for treatment, and highlight the urgent need ...

Prefrontal cortex drives the flexibility of whole-brain orchestration of cognition 

Kringelbach, Morten L.; Deco, Gustavo (Publication date: 2026-03-09)

The brain is hierarchically organised across many levels, from the underlying anatomical connectivity to the resulting functional dynamics, which supports the necessary orchestration to ensure sufficient cognitive and ...

Brain state identification and neuromodulation to promote recovery of consciousness 

Van Der Lande, Glenn J. M.; Casas-Torremocha, Diana; Manasanch, Arnau; Dalla Porta, Leonardo; Gosseries, Olivia; Alnagger, Naji; Barra, Alice; Mejias, Jorge F.; Panda, Rajanikant; Riefolo, Fabio; Thibaut, Aurore; Bonhomme, Vincent; Thirion, Bertrand; Clasca, Francisco; Gorostiza, Pau; Sanchez-Vives, Maria V.; Deco, Gustavo; Laureys, Steven; Zamora-López, Gorka; Annen, Jitka (Publication date: 2026-03-09)

Experimental and clinical studies of consciousness identify brain states (i.e. quasi-stable functional cerebral organization) in a non-systematic manner and largely independent of the research into brain state modulation. ...

Longitudinal study of knee pain amongst workers in the Cultural and Psychosocial Influences on Disability (CUPID) study 

Ntani, Georgia; Felli, Vanda E.; Harari, Fabiola; Barrero, Lope H.; Rojas, Marianela; Serra, Consol; Bonzini, Matteo; Merisalu, Eda; Habib, Rima R.; Sadeghian, Farideh; Wickremasinghe, Ananda R.; Matsudaira, Ko; Kelsall, Helen L.; Harcombe, Helen; Walker-Bone, Karen (Publication date: 2026-03-09)

Background: Knee pain is common in the general population, increasingly so with age. It causes substantial disability which can lead to premature exit from the workforce. Current epidemiological data on knee pain prevalence ...

Origins of life: the possible and the actual 

Solé Vicente, Ricard, 1962-; Kempes, Christopher; Stepney, Susan (Publication date: 2026-03-09)

The questions of how life forms, whether life is an inevitable outcome and how diverse its presentation could be remain some of the most profound in science. Investigations into the origin of life confront key issues such ...

Gut microbial modulation of 3-hydroxyanthranilic acid and dopaminergic signalling influences attention in obesity 

Castells-Nobau, Anna; Samulenaite, Solveiga; Martín García, Elena, 1975-; Maldonado, Rafael, 1961-; Mayneris Perxachs, Jordi (Publication date: 2026-03-09)

Background Obesity-related alterations in the gut microbiota have been linked to cognitive decline, yet their relationship with attention remains poorly understood. Objective To evaluate the possible relationships among ...

Fandom televisivo en España: estado de la cuestión 

Guerrero Pico, María del Mar; Establés, María-José (Publication date: 2026-03-09)

La popularización del visionado de ficción televisiva en España en las dos primeras décadas del siglo XXI, coincidiendo con la llamada Tercera Edad de Oro de la Televisión, es paralela al surgimiento de comunidades ...

Geometric phase in the Crow-Kimura model of molecular evolution on dynamic environments 

Suvorov, Vladimir; Solé Vicente, Ricard, 1962-; Saakian, David B. (Publication date: 2026-03-09)

When taking place under fluctuating environments, some classical results of evolutionary dynamics in fitness landscapes need to be reconsidered. Under such nonequilibrium conditions, the properties of adaptive evolution ...

Causes and consequences of disordered hyperuniformity in global drylands 

Hu, Wensi; Cui, Lijuan; Delgado-Baquerizo, Manuel; Solé Vicente, Ricard, 1962-; Kéfi, Sonia; Berdugo, Miguel; Xu, Nuo; Wang, Bo; Liu, Quan-Xing; Xu, Chi (Publication date: 2026-03-09)

Self-organization of individual organisms at a very small scale may result in recognizable functional ecosystem structures at a larger spatial scale. Drylands, which cover almost half of emerged lands, host some of the ...

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