dc.contributor
Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica
dc.contributor
Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.contributor
Universitat Politècnica de Catalunya. CETpD -Centre d'Estudis Tecnològics per a l'Atenció a la Dependència i la Vida Autònoma
dc.contributor.author
Bayés, Àngels
dc.contributor.author
Samà Monsonís, Albert
dc.contributor.author
Prats París, Anna
dc.contributor.author
Pérez López, Carlos
dc.contributor.author
Moreno Aróstegui, Juan Manuel
dc.contributor.author
Rodríguez Martín, Daniel Manuel
dc.contributor.author
Cabestany Moncusí, Joan
dc.date.issued
2018-01-01
dc.identifier
Bayés, À., Sama, A., Prats, A., Perez, C., Moreno, J., Rodriguez-Martin, D., Cabestany, J. A “HOLTER” for Parkinson's disease: validation of the ability to detect on-off states using the REMPARK system. "Gait and posture", 1 Gener 2018, vol. 59, p. 1-6.
dc.identifier
https://hdl.handle.net/2117/110568
dc.identifier
10.1016/j.gaitpost.2017.09.031
dc.description.abstract
The treatment of Parkinson's disease (PD) with levodopa is very effective. However, over time, motor complications (MCs) appear, restricting the patient from leading a normal life. One of the most disabling MCs is ON-OFF fluctuations. Gathering accurate information about the clinical status of the patient is essential for planning treatment and assessing its effect. Systems such as the REMPARK system, capable of accurately and reliably monitoring ON-OFF fluctuations, are of great interest. Objective To analyze the ability of the REMPARK System to detect ON-OFF fluctuations. Methods Forty-one patients with moderate to severe idiopathic PD were recruited according to the UK Parkinson's Disease Society Brain Bank criteria. Patients with motor fluctuations, freezing of gait and/or dyskinesia and who were able to walk unassisted in the OFF phase, were included in the study. Patients wore the REMPARK System for 3 days and completed a diary of their motor state once every hour. Results The record obtained by the REMPARK System, compared with patient-completed diaries, demonstrated 97% sensitivity in detecting OFF states and 88% specificity (i.e., accuracy in detecting ON states). Conclusion The REMPARK System detects an accurate evaluation of ON-OFF fluctuations in PD; this technology paves the way for an optimisation of the symptomatic control of PD motor symptoms as well as an accurate assessment of medication efficacy.
dc.description.abstract
Peer Reviewed
dc.description.abstract
Postprint (published version)
dc.format
application/pdf
dc.relation
http://www.gaitposture.com/article/S0966-6362(17)30936-0/fulltext
dc.rights
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.subject
Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica
dc.subject
Àrees temàtiques de la UPC::Informàtica::Intel·ligència artificial
dc.subject
Biomedical engineering
dc.subject
Automatic assessment
dc.subject
Motor complications
dc.subject
On-off fluctuations
dc.subject
Parkinson's disease
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REMPARK system
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Wearable sensor
dc.subject
Enginyeria biomèdica
dc.subject
Intel·ligència artificial -- Aplicacions a la medicina
dc.title
A “HOLTER” for Parkinson's disease: validation of the ability to detect on-off states using the REMPARK system
