dc.contributor
Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.contributor
Massachusetts Institute of Technology
dc.contributor
Kolandaivelu, Kumaran
dc.contributor
Vallverdú Ferrer, Montserrat
dc.contributor.author
De La Maza Prieto, Iñigo
dc.date.issued
2020-05-11
dc.identifier
https://hdl.handle.net/2117/187374
dc.identifier
ETSEIB-240.149360
dc.description.abstract
Anticoagulant drugs are essential treatments of cardiovascular diseases like myocardial infarction and stroke, but their effective use requires achieving a careful balance between suppressing pathological clotting (thrombosis) and compromising natural coagulation capabilities (hemostasis). Striking such a balance is difficult given the dynamic network of cellular and molecular reactions that take place in flowing blood. Embracing a systems pharmacology approach, computational and experimental models have been used to map the dynamic response of a novel class of Factor XI inhibitors, and explore their potential as anticoagulant medications with a wide risk/benefit margin. Systems pharmacology, computational model, blood coagulation.
dc.description.abstract
Outgoing
dc.format
application/pdf
dc.publisher
Universitat Politècnica de Catalunya
dc.rights
Restricted access - author's decision
dc.subject
Àrees temàtiques de la UPC::Informàtica::Automàtica i control
dc.subject
Blood--Coagulation
dc.subject
Sang -- Coagulació
dc.title
Tailoring systems pharmacology through computational models
