dc.contributor
Universitat Politècnica de Catalunya. Departament d'Enginyeria Química
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Universitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics
dc.contributor.author
Safari, Maryam
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Torres, Juan
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Pérez-Camargo, Ricardo
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Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon
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Múgica, Agurtzane
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Zubitur, Manuela
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Sardon Muguruza, Haritz
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Liu, Guoming
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Wang, Dujin
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Müller, Alejandro Jesús
dc.date.issued
2024-11-11
dc.identifier
Safari, M. [et al.]. How the aliphatic glycol chain length determines the pseudoeutectic composition in biodegradable isodimorphic poly(alkylene succinate-ran-caprolactone) random copolyesters. "Biomacromolecules", 11 Novembre 2024, vol. 25, núm. 11, p. 7392-7409.
dc.identifier
https://hdl.handle.net/2117/419787
dc.identifier
10.1021/acs.biomac.4c01073
dc.description.abstract
We synthesize four series of novel biodegradable poly(alkylene succinate-ran-caprolactone) random copolyesters using a two-step ring-opening/transesterification and polycondensation process with e-caprolactone (PCL) as a common comonomer. The second comonomers are succinic acid derivatives, with variations in the number of methylene groups (nCH2) in the glycol segment, nCH2 = 2, 4, 8, and 12. The obtained copolyesters were poly(ethylene succinate-ran-PCL) (ESxCLy), poly(butylene succinate-ran-PCL) (BSxCLy), poly(octamethylene succinate-ran-PCL) (OSxCLy), and poly(dodecylene succinate-ran-PCL) (DSxCLy). We discovered a new mixed isodimorphic/comonomer exclusion crystallization in ESxCLy copolymers. The BSxCLy, OSxCLy, and DSxCLy copolymers display isodimorphic behavior. Our findings revealed a significant variation in the pseudoeutectic point position, from mixed isodimorphism/comonomer exclusion crystallization to isodimorphism with pseudoeutectic point variation from 54% to up to 90%. Moreover, we established a link between the melting temperature depression slope variation and the comonomer inclusion/exclusion balance, providing valuable insights into the complex topic of isodimorphic random copolymers.
dc.description.abstract
This research was supported by the project PID2020-113045GB-C21, funded by MCIN/ AEI /10.13039/501100011033, and by the Basque Government through grant IT1503-22. G.L. acknowledges the support from the National Natural Science Foundation of China (22273113). R.A.P-C is supported by the ADAGIO-H2020-MSCA COFUND-2020 program (101034379). The authors performed the Synchrotron radiation WAXS/SAXS experiments at BL11-NCD-SWEET beamline at ALBA Synchrotron (Proposal Number 2020084441) with the collaboration of ALBA staff.
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Peer Reviewed
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Objectius de Desenvolupament Sostenible::11 - Ciutats i Comunitats Sostenibles
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Objectius de Desenvolupament Sostenible::9 - Indústria, Innovació i Infraestructura
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Postprint (author's final draft)
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application/pdf
dc.relation
https://pubs.acs.org/doi/10.1021/acs.biomac.4c01073?utm_source=SendGrid_ealert&utm_medium=ealert&utm_campaign=TOC_bomaf6_v25_i11
dc.relation
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095041-B-C33/ES/SISTEMAS DE LIBERACION DE FARMACOS BASADOS EN POLIMEROS AVANZADOS PARA EL TRATAMIENTO DE ENFERMEDADES GASTROINTESTINALES: POLIESTERES ANFIFILICOS Y BIOPOLIMEROS CARBOXILADOS/
dc.subject
Àrees temàtiques de la UPC::Enginyeria química
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Aliphatic copolyesters
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Random copolyesters
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Crystallization
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Pseudoeutectic point
dc.title
How the aliphatic glycol chain length determines the pseudoeutectic composition in biodegradable isodimorphic poly(alkylene succinate-ran-caprolactone) random copolyesters
