Fibrosis-induced arrhythmias: a computational approach to micro-reentries and ectopic foci

Abstract

Cardiac tissue is a prime example of a heterogeneous excitable system. Fibrosis is known to promote various types of cardiac arrhythmias by disrupting the normal propagation of electrical stimuli. In fibrotic tissue, conduction becomes more erratic and fragmented, leading to a noisy, breakable propagation pattern. The electrical wave follows a zigzag trajectory through a maze of non-conducting fibrotic regions.

Postprint (published version)