3D-StyleGAN2-ADA: Volumetric synthesis of realistic prostate T2W MRI

Abstract

This work investigates the extension of StyleGAN2-ADA to three-dimensional prostate T2-weighted (T2W) MRI generation. The architecture is adapted to operate on 3D anisotropic volumes, enabling stable training at a clinically relevant resolution of 256×256×24, where a baseline 3D-StyleGAN fails to converge. Quantitative evaluation using Fréchet Inception Distance (FID), Kernel Inception Distance (KID), and generative Precision–Recall metrics demonstrates substantial improvements over a 3D-StyleGAN baseline. Specifically, FID decreased from 114.2 to 27.3, while generative Precision increased from 0.22 to 0.82, indicating markedly improved fidelity and alignment with the real data distribution. Beyond generative metrics, the synthetic volumes were evaluated through radiomic feature analysis and downstream prostate segmentation. Synthetic data augmentation resulted in segmentation performance comparable to real-data training, supporting that volumetric generation preserves anatomically relevant structures, while multivariate radiomic analyses showed strong global feature alignment between real and synthetic volumes. These findings indicate that a 3D extension of StyleGAN2-ADA enables stable high-resolution volumetric prostate MRI synthesis while preserving anatomically coherent structure and global radiomic characteristics.

This work was supported by the European project Federated Learning and mUlti-party computation Techniques for prostatE cancer (HORIZON-101095382-FLUTE), the Spanish Research Agency (AEI) under project PID2023-148614OB-I00 funded by MICIU/AEI/10.13039/501100011033 and by FEDER, EU, and the FPI-Ministerio PRE-2021-098481 grant.

Peer Reviewed

Postprint (published version)