dc.contributor
Universitat Politècnica de Catalunya. Institut de Ciències Fotòniques
dc.contributor.author
Gabriel, Ramirez
dc.contributor.author
Proctor, Ashley R.
dc.contributor.author
Jung, Ki Won
dc.contributor.author
Wu, Tong Tong
dc.contributor.author
Han, Songfeng
dc.contributor.author
Adams, Russell R.
dc.contributor.author
Ren, Jingxuan
dc.contributor.author
Byun, Daniel K.
dc.contributor.author
Madden, Kelley S.
dc.contributor.author
Brown, Edward B.
dc.contributor.author
Foster, Thomas H.
dc.contributor.author
Farzam, Parisa
dc.contributor.author
Durduran, Turgut
dc.contributor.author
Choe, Regine
dc.date.issued
2016-09-01
dc.identifier
Gabriel, Ramirez [et al.]. Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy. "Biomedical Optics Express", 1 Setembre 2016, vol. 7, núm. 9, p. 3610-3630.
dc.identifier
https://hdl.handle.net/2117/90835
dc.description.abstract
The non-invasive, in vivo measurement of microvascular blood flow has the potential
to enhance breast cancer therapy monitoring. Here, longitudinal blood flow of 4T1 murine breast
cancer (N=125) under chemotherapy was quantified with diffuse correlation spectroscopy based
on layer models. Six different treatment regimens involving doxorubicin, cyclophosphamide,
and paclitaxel at clinically relevant doses were investigated. Treatments with cyclophosphamide
increased blood flow as early as 3 days after administration, whereas paclitaxel induced a
transient blood flow decrease at 1 day after administration. Early blood flow changes correlated
strongly with the treatme
dc.description.abstract
Peer Reviewed
dc.description.abstract
Postprint (published version)
dc.format
application/pdf
dc.relation
https://www.osapublishing.org/boe/abstract.cfm?uri=boe-7-9-3610
dc.rights
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.subject
Àrees temàtiques de la UPC::Física
dc.subject
Medical optics and biotechnology
dc.title
Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy
