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Título:
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African swine fever virus infection in Classical swine fever subclinically infected wild boars
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Autor/a:
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Cabezón Ponsoda, Óscar; Muñoz González, Sara; Colom-Cadena, Andreu; Rosell, Rosa; Lavín González, Santiago; Marco, Ignasi; Fraile Sauce, Lorenzo José; Martínez de la Riva, Paloma; Rodríguez, Fernando; Domínguez, Javier; Ganges, Llilianne
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Notas:
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Recently moderate-virulence classical swine fever virus (CSFV) strains have been proven capable of generating postnatal persistent infection (PI), defined by the maintenance of viremia and the inability to generate CSFV-specific immune responses in animals. These animals also showed a type I interferon blockade in the absence of clinical signs. In this study, we assessed the infection generated in 7-week-old CSFV PI wild boars after infection with the African swine fever virus (ASFV). The wild boars were divided in two groups and were infected with ASFV. Group A comprised boars who were CSFV PI in a subclinical form and Group B comprised pestivirus-free wild boars. Some relevant parameters related to CSFV replication and the immune response of CSFV PI animals were studied. Additionally, serum soluble factors such as IFN-α, TNF-α, IL-6, IL-10, IFN-γ and sCD163 were analysed before and after ASFV infection to assess their role in disease progression.
This research was supported by grants AGL2013–48998 and AGL2015–66907 from the Spanish government. S.M and A.C had |
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Materia(s):
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-CSFV
-CSF postnatal persistent infection
-Subclinical CSF
-ASFV |
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Derechos:
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cc-by (c) Cabezón et al., 2017
http://creativecommons.org/licenses/by/4.0/
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Tipo de documento:
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article
publishedVersion |
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Editor:
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BioMed Central
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Compartir:
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