Title:
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Synergistic antipseudomonal effects of synthetic peptide AMP38 and carbapenems
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Author:
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Rudilla, Héctor; Fusté i Domínguez, Ester; Cajal Visa, Yolanda; Rabanal Anglada, Francesc; Vinuesa Aumedes, Teresa; Viñas, Miquel
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Other authors:
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Universitat de Barcelona |
Abstract:
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The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem. |
Subject(s):
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-Pseudomonas -Síntesi de pèptids -Pèptids -Biofilms -Antibiòtics -Pseudomonas -Peptide synthesis -Peptides -Biofilms -Antibiotics |
Rights:
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cc-by (c) Rudilla, Héctor et al., 2016
http://creativecommons.org/licenses/by/3.0/es |
Document type:
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Article Article - Published version |
Published by:
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MDPI
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