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Títol:	ZRF1: a novel epigenetic regulator of stem cell identity and cancer
Autor/a:	Aloia, Luigi; Demajo Meseguer, Santiago, 1985-; Di Croce, Luciano
Abstract:	The Zuotin-related factor 1, ZRF1, has recently been identified as an epigenetic regulator of gene transcription in stem cells and cancer. During differentiation of human teratocarcinoma cells, ZRF1 promotes transcriptional induction of developmental genes that are repressed by Polycomb complexes. Importantly, ZRF1 has recently been shown to be required for both neural differentiation of embryonic stem cells (ESCs) and for maintenance of neural progenitor cell (NPC) identity. Moreover, a dual role has now emerged for ZRF1 in cancer: on the one hand, ZRF1 plays a crucial role in oncogene-induced senescence (OIS) by activating the INK4/ARF locus, thus working as a tumor suppressor; on the other hand, ZRF1 promotes leukemogenesis in acute myeloid leukemia (AML) in a Polycomb-independent fashion. Therefore, increasing evidence points to ZRF1 as a novel target for therapy of neurodegenerative diseases and cancer.
Abstract:	This work was supported by grants from the Spanish “Ministerio de Educación y Ciencia” (SAF2013-48926-P),/nAGAUR, AICR (10-0177), from the Fundación Vencer El Cáncer (VEC), and the European Commission's 7th Framework Program 4DCellFate grant number 277899 to L.D.C.
Matèries:	-Epigènesi -Càncer -Epigenetics -Transcription -Stem cells -Polycomb -Retinoic acid -Cell fate -Development -Cancer -Differentiation -Senescence -ZRF1
Drets:	© Taylor & Francis. This is an electronic version of an article published in Aloia L, Demajo S, Di Croce L. ZRF1: a novel epigenetic regulator of stem cell identity and cancer. Cell cycle. 2015; 14(4): 510-515. DOI 10.4161/15384101.2014.988022. Cell cycle is available online at: http://www.tandfonline.com/doi/full/10.4161/15384101.2014.988022
Tipus de document:	Article Article - Versió acceptada
Publicat per:	Taylor & Francis (Routledge)
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