Ferrocene derivatives of liquid chiral molecules allow for absolute structure determination by X-ray crystallography

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Empreu aquest identificador per citar o enllaçar aquest document: http://hdl.handle.net/2072/335517

Títol:	Ferrocene derivatives of liquid chiral molecules allow for absolute structure determination by X-ray crystallography
Autor/a:	Holstein, Philipp M.; Holstein, Julian J.; Escudero, Eduardo C.; Baudoin, Olivier; Echavarren, Antonio M.
Abstract:	The present study investigates a synthetically simple ferrocene derivatization of natural products and active pharmaceutical ingredients. Seven new crystal structures are analyzed together with 16 structures of ferrocene derivatives reported previously. In all cases the unambiguous determination of the absolute structure was established from anomalous dispersion using the methods of Flack, Hooft and Parsons. A comparison with other derivatization approaches shows the advantage of the herein described ferrocene derivatization for establishing the absolute configuration of novel compounds.
Data de publicació:	01-09-2017
Matèries:	54
Drets:	L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/
Pàgines:	1321 p.
Tipus de document:	Article Article - Versió acceptada
DOI:	10.1016/j.tetasy.2017.09.002
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