Título:
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Guillain-Barré syndrome following the 2009 pandemic monovalent and seasonal trivalent influenza vaccination campaigns in Spain from 2009 to 2011: outcomes from active surveillance by a neurologist network, and records from a country-wide hospital discharge database
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Autor/a:
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Alcalde Cabero, Enrique; Almazan Isla, Javier; García López, Fernando J.; Ara Callizo, José Ramón; Avellanal, Fuencisla; Casasnovas Pons, Carlos; Cemillán, Carlos; Cuadrado, José Ignacio; Duarte, Jacinto; Fernández Pérez, María Dolores; Fernández, Óscar; García Merino, Juan Antonio; García Montero, Rosa; Montero, Dolores; Pardo, Julio; Rodríguez Rivera, Francisco Javier; Ruiz Tovar, María; Pedro Cuesta, Jesús de; Spanish GBS Epidemiology Study Group
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Otros autores:
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Universitat de Barcelona |
Abstract:
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Background: Studies have shown a slight excess risk in Guillain-Barre syndrome (GBS) incidence associated with A(H1N1) pdm09 vaccination campaign and seasonal trivalent influenza vaccine immunisations in 2009-2010. We aimed to assess the incidence of GBS as a potential adverse effect of A(H1N1) pdm09 vaccination. Methods: A neurologist-led network, active at the neurology departments of ten general hospitals serving an adult population of 4.68 million, conducted GBS surveillance in Spain in 2009-2011. The network, established in 1996, carried out a retrospective and a prospective study to estimate monthly alarm thresholds in GBS incidence and tested them in 1998-1999 in a pilot study. Such incidence thresholds additionally to observation of GBS cases with immunisation antecedent in the 42 days prior to clinical onset were taken as alarm signals for 2009-2011, since November 2009 onwards. For purpose of surveillance, in 2009 we updated both the available centres and the populations served by the network. We also did a retrospective countrywide review of hospital-discharged patients having ICD-9-CM code 357.0 (acute infective polyneuritis) as their principal diagnosis from January 2009 to December 2011. Results: Among 141 confirmed of 148 notified cases of GBS or Miller-Fisher syndrome, Brighton 1-2 criteria in 96 %, not a single patient was identified with clinical onset during the 42-day time interval following A(H1N1) pdm09 vaccination. In contrast, seven cases were seen during a similar period after seasonal campaigns. Monthly incidence figures did not, however, exceed the upper 95 % CI limit of expected incidence. A retrospective countrywide review of the registry of hospital-discharged patients having ICD-9-CM code 357.0 (acute infective polyneuritis) as their principal diagnosis did not suggest higher admission rates in critical months across the period December 2009-February 2010. Conclusions: Despite limited power and underlying reporting bias in 2010-2011, an increase in GBS incidence over background GBS, associated with A(H1N1) pdm09 monovalent or trivalent influenza immunisations, appears unlikely. |
Materia(s):
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-Malalties autoimmunitàries -Nervis perifèrics -Influenzavirus -Grip -Vacunes -Autoimmune diseases -Peripheral nerves -Influenza viruses -Influenza -Vaccines |
Derechos:
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cc-by (c) Alcalde Cabero, Enrique et al., 2016
http://creativecommons.org/licenses/by/3.0/es |
Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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BioMed Central
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