Title:
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Allosterism and signal transfer in DNA
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Author:
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Balaceanu, Alexandra; Pérez, Alberto; Dans, Pablo D.; Orozco López, Modesto
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Other authors:
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Universitat de Barcelona |
Abstract:
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We analysed the basic mechanisms of signal transmission in DNA and the origins of the allostery exhibited by systems such as the ternary complex BAMHI-DNA-GRDBD. We found that perturbation information generated by a primary protein binding event travels as a wave to distant regions of DNA following a hopping mechanism. However, such a structural perturbation is transient and does not lead to permanent changes in the DNA geometry and interaction properties at the secondary binding site. The BAMHI-DNA-GRDBD allosteric mechanism does not occur through any traditional models: direct (protein-protein), indirect (reorganization of the secondary site) readout or solvent-release. On the contrary, it is generated by a subtle and less common entropy-mediated mechanism, which might have an important role to explain other DNA-mediated cooperative effects. |
Subject(s):
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-ADN -Dinàmica molecular -Proteïnes -Lligands -DNA -Molecular dynamics -Proteins -Ligands |
Rights:
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cc-by-nc (c) Balaceanu, Alexandra et al., 2018
http://creativecommons.org/licenses/by-nc/3.0/es |
Document type:
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Article Article - Published version |
Published by:
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Oxford University Press
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