High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement

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Title:	High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement
Author:	Montero, Maria Milagro; Mir Fontana, M. Luisa; Sulleiro, Elena; Avalos Esquivel J.L.; García López, E.; Molina-Morant, D.; López Montesinos, I.; Sorli Redó, M. Luisa; Veliz Espinosa, G.; Mounteis Oliva, E.; Crespo Barrio, Marta; Monge, I.; Horcajada Gallego, Juan Pablo; Grau Cerrato, Santiago; Pascual Santos, Julio
Abstract:	There is little published data on benznidazole dosing, or levels in cerebrospinal fluid. In this report, we describe the clinical course of an immunosuppressed patient with Chagas central nervous system involvement. He was treated successfully with larger benznidazole doses than are recommended, in order to reach therapeutically effective concentrations in the brain.
Subject(s):	-Chagas, Malaltia de -Ronyons -- Trasplantació -Benznidazole PK/PD -Benznidazole dose -Chagas disease -Chagoma -Kidney transplant recipient
Rights:	1201-9712/© 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). http://creativecommons.org/licenses/by-nc-nd/4.0/
Document type:	Article Article - Published version
Published by:	Elsevier
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