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Título:	The plasma membrane as a mechanochemical transducer
Autor/a:	Roux, Anabel-Lise Le; Quiroga, Xarxa; Walani, Nikhil; Arroyo, Marino; Roca-Cusachs Soulere, Pere
Otros autores:	Universitat de Barcelona
Abstract:	Cells are constantly submitted to external mechanical stresses, which they must withstand and respond to. By forming a physical boundary between cells and their environment that is also a biochemical platform, the plasma membrane (PM) is a key interface mediating both cellular response to mechanical stimuli, and subsequent biochemical responses. Here, we review the role of the PM as a mechanosensing structure. We first analyse how the PM responds to mechanical stresses, and then discuss how this mechanical response triggers downstream biochemical responses. The molecular players involved in PM mechanochemical transduction include sensors of membrane unfolding, membrane tension, membrane curvature or membrane domain rearrangement. These sensors trigger signalling cascades fundamental both in healthy scenarios and in diseases such as cancer, which cells harness to maintain integrity, keep or restore homeostasis and adapt to their external environment.
Materia(s):	-Membranes cel·lulars -Càncer -Cell membranes -Cancer
Derechos:	cc by (c) Roux et al., 2019 http://creativecommons.org/licenses/by/3.0/es/
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	The Royal Society Publishing
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