Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/111722

Título:	A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma
Autor/a:	Navarro Ponz, Alfons; Díaz Sánchez, Tania; Tovar, Natalia; Pedrosa, Fabiola; Tejero Villalba, Rut; Cibeira, María Teresa; Magnano, Laura; Rosiñol Dachs, Laura; Monzó Planella, Mariano; Bladé, J. (Joan); Fernández de Larrea Rodríguez, Carlos José
Notas:	We have examined serum microRNA expression in multiple myeloma (MM) patients at diagnosis and at complete response (CR) after autologous stem-cell transplantation (ASCT), in patients with stable monoclonal gammopathy of undetermined significance, and in healthy controls. MicroRNAs were first profiled using TaqMan Human MicroRNA Arrays. Differentially expressed microRNAs were then validated by individual TaqMan MicroRNA assays and correlated with CR and progression-free survival (PFS) after ASCT. Supervised analysis identified a differentially expressed 14-microRNA signature. The differential expression of miR-16 (P = 0.028), miR-17 (P = 0.016), miR-19b (P = 0.009), miR-20a (P = 0.017) and miR-660 (P = 0.048) at diagnosis and CR was then confirmed by individual assays. In addition, high levels of miR-25 were related to the presence of oligoclonal bands (P = 0.002). Longer PFS after ASCT was observed in patients with high levels of miR-19b (6 vs. 1.8 years; P < 0.001) or miR-331 (8.6 vs. 2.9 years; P = 0.001). Low expression of both miR-19b and miR-331 in combination was a marker of shorter PFS (HR 5.3; P = 0.033). We have identified a serum microRNA signature with potential as a diagnostic and prognostic tool in MM.
Materia(s):	-Micro RNAs -Sèrum -Mielomatosi -Trasplantament d'òrgans -MicroRNAs -Serum -Myeloproliferative disorders -Transplantation of organs
Derechos:	cc-by (c) Navarro Ponz, Alfons et al., 2014 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Impact Journals
Compartir:

Mostrar el registro completo del ítem