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Title:	Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction
Author:	Miranda, Jezid; Simões, Rui V.; Paules, Cristina; Cañueto, Daniel; Pardo Cea, Miguel A.; García Martín, María L.; Crovetto, Francesca; Fuertes Martin, Rocio; Doménech, Mónica; Gómez Roig, Ma. Dolores; Eixarch Roca, Elisenda; Estruch Riba, Ramon; Hansson, Stefan R.; Amigó, Núria; Cañellas, Nicolau; Crispi Brillas, Fàtima; Gratacós Solsona, Eduard
Notes:	Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical properties. Lipoprotein profiles showed significantly lower plasma concentrations of cholesterol-intermediate density lipoprotein (IDL), triglycerides-IDL and high-density lipoprotein (HDL) in mothers of growth-restricted fetuses compared to controls (p < 0.05). In contrast, growth-restricted fetuses had significantly higher plasma concentrations of cholesterol and triglycerides transporting lipoproteins [LDL, IDL, and VLDL, (p < 0.005; all)], as well as increased VLDL particle types (large, medium and small). Significant changes in plasma concentrations of formate, histidine, isoleucine and citrate in growth-restricted fetuses were also observed. Comprehensive metabolic profiling reveals that both, mother and fetuses of pregnancies complicated with fetal growth restriction have a substantial disruption in lipid metabolism.
Subject(s):	-Creixement fetal -Metabòlits -Placenta -Metabolisme cel·lular -Fetal growth -Metabolites -Placenta -Cell metabolism
Rights:	cc-by (c) Miranda, Jezid et al., 2018 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	Nature Publishing Group
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