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Title:	Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials
Author:	Montal, Robert; Andreu Oller, Carmen; Bassaganyas, Laia; Esteban Fabró, Roger; Moran, Sebastian; Montironi, Carla; Moeini, Agrin; Pinyol, Roser; Peix, Judit; Cabellos, Laia; Villanueva, Augusto; Sia, Daniela; Mazzaferro, Vincenzo; Esteller, Manel; Llovet i Bayer, Josep Maria
Notes:	The clinical utility of serum alpha-fetoprotein (AFP) in patients with hepatocellular carcinoma (HCC) is widely recognised. However, a clear understanding of the mechanisms of AFP overexpression and the molecular traits of patients with AFP-high tumours are not known. We assessed transcriptome data, whole-exome sequencing data and DNA methylome profiling of 520 HCC patients from two independent cohorts to identify distinct molecular traits of patients with AFP-high tumours (serum concentration?>?400?ng/ml), which represents an accepted prognostic cut-off and a predictor of response to ramucirumab. Those AFP-high tumours (18% of resected cases) were characterised by significantly lower AFP promoter methylation (p?
Subject(s):	-Càncer de fetge -Oncogènesi -Liver cancer -Carcinogenesis
Rights:	(c) Montal et al., 2019
Document type:	Article Article - Published version
Published by:	Nature Publishing Group
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