dc.contributor.author
Herranz Martín, Nicolás
dc.contributor.author
Dave, Natàlia
dc.contributor.author
Millanes Romero, Alba, 1986-
dc.contributor.author
Morey Ramonell, Lluís
dc.contributor.author
Díaz, Víctor M.
dc.contributor.author
Lórenz Fonfria, Víctor
dc.contributor.author
Gutiérrez Gallego, Ricardo, 1968-
dc.contributor.author
Jerónimo, Celia
dc.contributor.author
Di Croce, Luciano
dc.contributor.author
García de Herreros, Antonio
dc.contributor.author
Peiró Sales, Sandra
dc.date.issued
2015-12-11T15:19:17Z
dc.date.issued
2015-12-11T15:19:17Z
dc.identifier
Herranz N, Dave N, Millanes-Romero A, Morey L, Díaz VM, Lórenz-Fonfría V et al. Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. Molecular cell. 2012;46(3):369-76. DOI: 10.1016/j.molcel.2012.03.002
dc.identifier
http://hdl.handle.net/10230/25392
dc.identifier
http://dx.doi.org/10.1016/j.molcel.2012.03.002
dc.description.abstract
Methylation of lysine 4 (K4) within histone H3 has been linked to active transcription and is removed by LSD1 and the JmjC domain-containing proteins by amino-oxidation or hydroxylation, respectively. Here, we describe the deamination catalyzed by Lysyl oxidase-like 2 protein (LOXL2) as an unconventional chemical mechanism for H3K4 modification. Infrared spectroscopy and mass spectrometry analyses demonstrated that recombinant LOXL2 specifically deaminates trimethylated H3K4. Moreover, LOXL2 activity is linked with the transcriptional control of CDH1 gene by regulating H3K4me3 deamination. These results reveal another H3 modification and provide a different mechanism for H3K4 modification.
dc.format
application/pdf
dc.format
application/pdf
dc.publisher
American Society for Cell Biology
dc.relation
Molecular cell. 2012;46(3):369-76
dc.rights
© Elsevier. This is the published version of an article http://dx.doi.org/10.1016/j.molcel.2012.03.002 that appeared in the journal Molecular cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-license
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Regulació genètica
dc.title
Lysyl oxidase-like 2 deaminates lysine 4 in histone H3
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
