dc.contributor.author
Talló Parra, Marc, 1992-
dc.contributor.author
Muscolino, Elena
dc.contributor.author
Díez Antón, Juana, 1962-
dc.date.issued
2023-03-02T07:05:37Z
dc.date.issued
2023-03-02T07:05:37Z
dc.identifier
Talló-Parra M, Muscolino E, Díez J. The host tRNA epitranscriptome: A new player in RNA virus infections. Front Virol. 2022;2:1073619. DOI: 10.3389/fviro.2022.1073619
dc.identifier
http://hdl.handle.net/10230/56009
dc.identifier
http://dx.doi.org/10.3389/fviro.2022.1073619
dc.description.abstract
Viruses completely depend on the host translation machineries to express the viral proteins. Recent data reveal an unprecedented interaction of positive strand RNA ((+)RNA) viruses with the host tRNA epitranscriptome to favor viral protein expression via a specific reprogramming of codon optimality that ultimately favors decoding of the viral codons. We propose that this feature is shared by multiple RNA viruses and that the involved tRNA modifying enzymes represent promising novel targets for the development of broad-spectrum antivirals.
dc.description.abstract
This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness (AEI/MINECO/FEDER, UE; PID2019-106959RB-I00) and the “Unidad de Excelencia María de Maeztu” funded by the AEI (CEX2018-000792-M).
dc.format
application/pdf
dc.format
application/pdf
dc.relation
Front Virol. 2022;2:1073619
dc.relation
info:eu-repo/grantAgreement/ES/2PE/PID2019-106959RB-I00
dc.rights
© 2022 Talló-Parra, Muscolino and Díez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
tRNA modifications
dc.subject
tRNA epitranscriptome
dc.subject
(+)RNA viruses
dc.title
The host tRNA epitranscriptome: A new player in RNA virus infections
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
