Universitat de Lleida
2019-11-12T09:40:01Z
2019-11-12T09:40:01Z
2018-11-16
2019-11-12T09:40:01Z
Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meaning that mitochondrial calcium uptake and release is intimately related to cytosolic calcium concentrations. This review focuses on the proteins contributing to mitochondrial calcium homoeostasis, the roles of the mitochondrial permeability transition pore (MPTP) and mitochondrial calcium-activated proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA).
This work was supported by the Spanish Ministerio de Economía, Industria y Competitividad [grant number SAF2017-83883-R]; and the Ataxia U.K./Ireland and ACAH for supporting our lab.
Article
Published version
English
Portland Press
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-83883-R/ES/TARGETING MITOCHONDRIA IN FRIEDREICH ATAXIA: MOLECULAR MECHANISMS AND THERAPEUTIC APPROACHES/
Reproducció del document publicat a https://doi.org/10.1042/NS20180061
Neuronal signaling, 2018, vol. 2, núm. 4, p. NS20180061
cc-by (c) Elena Britti et al., 2018
http://creativecommons.org/licenses/by/4.0/
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