dc.contributor.author
Britti, Elena
dc.contributor.author
Delaspre, Fabien
dc.contributor.author
Tamarit Sumalla, Jordi
dc.contributor.author
Ros Salvador, Joaquim
dc.date.accessioned
2024-12-05T22:21:48Z
dc.date.available
2024-12-05T22:21:48Z
dc.date.issued
2019-11-12T09:40:01Z
dc.date.issued
2019-11-12T09:40:01Z
dc.date.issued
2018-11-16
dc.date.issued
2019-11-12T09:40:01Z
dc.identifier
https://doi.org/10.1042/NS20180061
dc.identifier
http://hdl.handle.net/10459.1/67520
dc.identifier.uri
https://hdl.handle.net/10459.1/67520
dc.description.abstract
Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meaning that mitochondrial calcium uptake and release is intimately related to cytosolic calcium concentrations. This review focuses on the proteins contributing to mitochondrial calcium homoeostasis, the roles of the mitochondrial permeability transition pore (MPTP) and mitochondrial calcium-activated proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA).
dc.description.abstract
This work was supported by the Spanish Ministerio de Economía, Industria y Competitividad [grant number SAF2017-83883-R]; and the Ataxia U.K./Ireland and ACAH for supporting our lab.
dc.format
application/pdf
dc.publisher
Portland Press
dc.relation
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-83883-R/ES/TARGETING MITOCHONDRIA IN FRIEDREICH ATAXIA: MOLECULAR MECHANISMS AND THERAPEUTIC APPROACHES/
dc.relation
Reproducció del document publicat a https://doi.org/10.1042/NS20180061
dc.relation
Neuronal signaling, 2018, vol. 2, núm. 4, p. NS20180061
dc.rights
cc-by (c) Elena Britti et al., 2018
dc.rights
info:eu-repo/semantics/openAccess
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.subject
Sistema nerviós -- Degeneració
dc.title
Mitochondrial calcium signaling and neurodegenerative diseases
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
