dc.contributor.author
Millán Acosta, Alberto
dc.contributor.author
Sala i Martí, Núria
dc.contributor.author
Torres i Grifo, Mercè
dc.contributor.author
Canela i Garayoa, Ramon
dc.date.accessioned
2024-12-05T21:45:33Z
dc.date.available
2024-12-05T21:45:33Z
dc.date.issued
2021-02-22T10:42:08Z
dc.date.issued
2021-02-22T10:42:08Z
dc.date.issued
2021-02-06
dc.identifier
https://doi.org/10.3390/catal11020216
dc.identifier
http://hdl.handle.net/10459.1/70579
dc.identifier.uri
http://hdl.handle.net/10459.1/70579
dc.description.abstract
The compound 2,5-di(hydroxymethyl)furan (DHMF) is a high-value chemical block that can be synthesized from 5-hydroxymethylfurfural (HMF), a platform chemical that results from the dehydration of biomass-derived carbohydrates. In this work, the HMF biotransformation capability of different Fusarium species was evaluated, and F. striatum was selected to produce DHMF. The effects of the inoculum size, glucose concentration and pH of the media over DHMF production were evaluated by a 23 factorial design. A substrate feeding approach was found suitable to overcome the toxicity effect of HMF towards the cells when added at high concentrations (>75 mM). The process was successfully scaled-up at bioreactor scale (1.3 L working volume) with excellent DHMF production yields (95%) and selectivity (98%). DHMF was purified from the reaction media with high recovery and purity by organic solvent extraction with ethyl acetate.
dc.description.abstract
This work was partially supported by the Spanish government (PID2019-110735RB-C21, MICIN/FEDER) and the Catalan Government (FI_B1_00135).
dc.relation
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110735RB-C21/ES/APLICACION DE DISOLVENTES IONICOS EUTECTICOS BASADOS EN PRODUCTOS NATURALES A LA VALORIZACION DE BIOMASA NO ALIMENTARIA/
dc.relation
Reproducció del document publicat a: https://doi.org/10.3390/catal11020216
dc.relation
Catalysts, 2021, vol. 11, núm. 2, p. 216
dc.rights
cc-by (c) Millán, Alberto et al., 2021
dc.rights
info:eu-repo/semantics/openAccess
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.subject
Biotransformation
dc.subject
Platform chemical
dc.title
Biocatalytic Transformation of 5-Hydroxymethylfurfural into 2,5-di(hydroxymethyl)furan by a Newly Isolated Fusarium striatum Strain
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
