dc.contributor
Institut Català de la Salut
dc.contributor
[Saoudi González N, Ros J, Baraibar I, Salvà F, Rodríguez-Castells M, Alcaraz A, Tabernero J, Élez E] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [García A] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
García Morales, Ariadna
dc.contributor.author
Saoudi Gonzalez, Nadia
dc.contributor.author
Ros, Javier
dc.contributor.author
Baraibar, Iosune
dc.contributor.author
Salvà, Francesc
dc.contributor.author
R Castells, Marta
dc.contributor.author
Alcaraz Soler, Adriana
dc.contributor.author
Tabernero, Josep
dc.contributor.author
Elez, Elena
dc.date.accessioned
2024-06-06T08:40:50Z
dc.date.available
2024-06-06T08:40:50Z
dc.date.issued
2024-02-16T08:34:17Z
dc.date.issued
2024-02-16T08:34:17Z
dc.date.issued
2024-01-18
dc.identifier
Saoudi González N, Ros J, Baraibar I, Salvà F, Rodríguez-Castells M, Alcaraz A, et al. Cetuximab as a Key Partner in Personalized Targeted Therapy for Metastatic Colorectal Cancer. Cancers (Basel). 2024 Jan;16(2):412.
dc.identifier
https://hdl.handle.net/11351/11057
dc.identifier
10.3390/cancers16020412
dc.identifier
001151894500001
dc.identifier.uri
https://hdl.handle.net/11351/11057
dc.description.abstract
Cetuximab; Colorectal cancer; Personalized treatment
dc.description.abstract
Cetuximab; Càncer de colorectal; Tracte personalitzat
dc.description.abstract
Cetuximab; Cáncer colorrectal; Trato personalizado
dc.description.abstract
Cetuximab, a chimeric IgG1 monoclonal antibody targeting the epidermal growth factor receptor (EGFR), has revolutionized personalized treatment of metastatic colorectal cancer (mCRC) patients. This review highlights the mechanism of action, characteristics, and optimal indications for cetuximab in mCRC. Cetuximab has emerged as a pivotal partner for novel therapies in specific molecular subgroups, including BRAF V600E, KRAS G12C, and HER2-altered mCRC. Combining cetuximab with immunotherapy and other targeted agents further expands the therapeutic landscape, offering renewed hope for mCRC patients who face the development of resistance to conventional therapies. Ongoing clinical trials have continued to uncover innovative cetuximab-based treatment strategies, promising a brighter future for mCRC patients. This review provides a comprehensive overview of cetuximab’s role and its evolving importance in personalized targeted therapy of mCRC patients, offering valuable insights into the evolving landscape of colorectal cancer treatment.
dc.format
application/pdf
dc.relation
Cancers;16(2)
dc.relation
https://doi.org/10.3390/cancers16020412
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Còlon - Càncer - Tractament
dc.subject
Recte - Càncer - Tractament
dc.subject
Anticossos monoclonals - Ús terapèutic
dc.subject
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
dc.subject
Other subheadings::Other subheadings::Other subheadings::/drug therapy
dc.subject
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal
dc.subject
Other subheadings::Other subheadings::/therapeutic use
dc.subject
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales
dc.subject
Otros calificadores::Otros calificadores::/uso terapéutico
dc.title
Cetuximab as a Key Partner in Personalized Targeted Therapy for Metastatic Colorectal Cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
